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Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase

文献类型：期刊论文

作者Li, Jin-Sheng1; Liu, Yi-Nan1,3; Li, Jing-Ya3,4; Lei, Chun1; Hou, Ai-Jun1,2
刊名PHYTOCHEMISTRY
出版日期2023-03-01
卷号207页码:7
ISSN号0031-9422
关键词Eucalyptus tereticornis Smith Myrtaceae Meroterpenoids (+)- (-)-eucateretins A-E ATP citrate Lyase
DOI10.1016/j.phytochem.2022.113565
通讯作者Lei, Chun(chunlei@fudan.edu.cn) ; Hou, Ai-Jun(ajhou@shmu.edu.cn)
英文摘要Five undescribed enantiomeric pairs of acylphloroglucinol-monoterpene meroterpenoids ((+)-/(-)-eucateretins A-E) resolved by chiral-phase HPLC were obtained from the leaves of Eucalyptus tereticornis Smith, along with nine known analogues. Their structures were elucidated by spectroscopic methods and ECD calculations. This is the first report of meroterpenoid enantiomers from this plant. Some of the isolates, (-)-eucateretin A, (+)-/(-)-eucateretins E, 7 'alpha-eucalrobusone X, eucalrobusone X, and robustadial B, exhibited inhibitory effects on ATP citrate lyase, and 7 'alpha-eucalrobusone X significantly suppressed the hepatocyte lipogenesis.
WOS关键词FORMYL-PHLOROGLUCINOL MEROTERPENOIDS ; BIOMIMETIC SYNTHESIS ; ENANTIOMERIC PAIRS ; ROBUSTADIAL-A ; LEAVES ; EUGLOBAL-G3
资助项目National Natural Science Foundation of China[22277074] ; National Natural Science Foundation of China[82073717]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000913963500001
源URL[http://119.78.100.183/handle/2S10ELR8/303555]  
专题中国科学院上海药物研究所
通讯作者Lei, Chun; Hou, Ai-Jun
作者单位1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jin-Sheng,Liu, Yi-Nan,Li, Jing-Ya,et al. Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase[J]. PHYTOCHEMISTRY,2023,207:7.
APA Li, Jin-Sheng,Liu, Yi-Nan,Li, Jing-Ya,Lei, Chun,&Hou, Ai-Jun.(2023).Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase.PHYTOCHEMISTRY,207,7.
MLA Li, Jin-Sheng,et al."Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase".PHYTOCHEMISTRY 207(2023):7.

入库方式： OAI收割

来源：上海药物研究所

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