Metal-Organic Frameworks for Gene Therapy and Detection
文献类型：期刊论文
| 作者 | He, Yaping1; Li, Daifeng2; Wu, Li3; Yin, Xianzhen3; Zhang, Xiaojian1; Patterson, Laurence H.4; Zhang, Jiwen3
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2023-01-12 |
| 页码 | 16 |
| ISSN号 | 1616-301X |
| 关键词 | gene delivery metal-organic frameworks (MOFs) polynucleotide and oligonucleotide delivery and detection targeted nanoplatforms |
| DOI | 10.1002/adfm.202212277 |
| 通讯作者 | Zhang, Xiaojian(fcczhangxj@zzu.edu.cn) ; Patterson, Laurence H.(l.h.patterson@bradford.ac.uk) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Gene therapy holds great promise as a biomedicine for treating cancer, viral infection, and recessive gene disorders, while genetic detection has been used for disease diagnosis and prevention. The appropriate carrier is crucial to improve the delivery efficiency of nucleic acids. Although viral and nonviral delivery vectors have been developed, their poor nucleic acid loading efficiency, off-target toxicity, and immunogenicity significantly hamper their use. Metal-organic frameworks (MOFs) have attracted a lot of attention owing to their high surface areas and tunable structures. Recently, nanometric MOFs are shown to be promising nonviral vectors in gene delivery and detection although at an early stage of development. This review focuses on highlighting the current status and promising breakthroughs of MOF use in nucleic acid delivery, including siRNA, miRNA and mRNA delivery, DNA gene delivery and transfection, as well as probes for detection of gene expression. This study will help promote the clinical transformation and application of gene modulation, gene delivery, and detection that use of MOFs can offer. |
| WOS关键词 | RATIONAL DESIGN ; POOLED SIRNAS ; DELIVERY ; NANOPARTICLES ; RESISTANT ; CELLS ; NANOCARRIERS ; NANOPLATFORM ; SEPARATION ; STRATEGIES |
| 资助项目 | National Natural Science Foundation of China[82104086] ; Joint Construction Projects of Medical Science and Technology of Henan Province[LHGJ20210279] ; National Key R&D Program of China[2020YFE0201700] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000912533500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303558]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Xiaojian; Patterson, Laurence H.; Zhang, Jiwen |
| 作者单位 | 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou 450052, Peoples R China 2.Zhengzhou Univ, Affiliated Hosp 1, Dept Orthoped, Zhengzhou 450052, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Univ Bradford, Inst Canc Therapeut, Fac Life Sci, Bradford BD7 1DP, West Yorkshire, England |
| 推荐引用方式 GB/T 7714 | He, Yaping,Li, Daifeng,Wu, Li,et al. Metal-Organic Frameworks for Gene Therapy and Detection[J]. ADVANCED FUNCTIONAL MATERIALS,2023:16. |
| APA | He, Yaping.,Li, Daifeng.,Wu, Li.,Yin, Xianzhen.,Zhang, Xiaojian.,...&Zhang, Jiwen.(2023).Metal-Organic Frameworks for Gene Therapy and Detection.ADVANCED FUNCTIONAL MATERIALS,16. |
| MLA | He, Yaping,et al."Metal-Organic Frameworks for Gene Therapy and Detection".ADVANCED FUNCTIONAL MATERIALS (2023):16. |
入库方式： OAI收割
来源：上海药物研究所
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