Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production
文献类型：期刊论文
| 作者 | Cao, Jing-Ya1,2,3; Wang, Zhi-Yao4; Stewart, Alan J. J.5; Dong, Qi1,2; Zhao, Ye6; Mei, Li-Juan1,2; Tao, Yan-Duo1,2; Yu, Rui-Tao1,2,7 |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2023-01-10 |
| 页码 | 11 |
| 关键词 | Saussurea medusa Asteraceae diarylbutyrolactone lignan sesquilignan anti-inflammatory activity molecular docking |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/a-1956-7829 |
| 通讯作者 | Yu, Rui-Tao(yuruitao@nwipb.cas.cn) |
| 英文摘要 | Five new diarylbutyrolactones and sesquilignans ( 1a/1b - 4 ), including one pair of enantiomers ( 1a/1b ), together with 10 known analogues ( 5 - 14 ), were isolated from the whole plants of Saussurea medusa . Compound 1 was found to possess an unusual 7,8 ' -diarylbutyrolactone lignan structure. Separation by chiral HPLC analysis led to the isolation of one pair of enantiomers, (+)- 1a and (-)- 1b . The structures of the new compounds were elucidated by extensive spectroscopic data. All compounds, except compounds 5, 7 and 9 , were isolated from S. medusa for the first time. Moreover, compounds 1 - 4, 8 and 10 - 14 had never been obtained from the genus Saussurea previously. Compounds (+)- 1a, 2, 5, 7 , and 9 - 11 were found to inhibit the lipopolysaccharide (LPS)-induced release of NO by RAW264.7 cells with IC (50) values ranging from 10.1 +/- 1.8 to 41.7 +/- 2.1 mu M. Molecular docking and iNOS expression experiments were performed to examine the interactions between the active compounds and the iNOS enzyme. |
| WOS关键词 | ARCTIUM-LAPPA ; LIGNANS ; ARCTIGENIN ; EXPRESSION ; ROOT |
| 资助项目 | Natural Science Foundation of Qinghai Province ; science and innovation platform for the development and construction of special projects of Key Laboratory of Tibetan Medicine Research of Qinghai Province ; [?2022-ZJ-930] ; [?2022-ZJ-Y03] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000911771200008 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303570]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Rui-Tao |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Henan Acad Sci, Zhengzhou, Peoples R China 5.Univ St Andrews, Sch Med, St Andrews, Scotland 6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 7.Chinese Acad Sci, Northwest Inst Plateau Biol, Xinning Rd 23, Xining 810008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Jing-Ya,Wang, Zhi-Yao,Stewart, Alan J. J.,et al. Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production[J]. PLANTA MEDICA,2023:11. |
| APA | Cao, Jing-Ya.,Wang, Zhi-Yao.,Stewart, Alan J. J..,Dong, Qi.,Zhao, Ye.,...&Yu, Rui-Tao.(2023).Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production.PLANTA MEDICA,11. |
| MLA | Cao, Jing-Ya,et al."Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production".PLANTA MEDICA (2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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