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Promote Intratumoral Drug Release and Penetration to Counteract Docetaxel-Induced Metastasis by Photosensitizer-Modified Red Blood Cell Membrane-Coated Nanoparticle

文献类型：期刊论文

作者Wu, Ting2,3,4; Lang, Tianqun3,4,5; Zheng, Chao3,4; Yan, Wenlu1,3,4; Li, Yu3,4,5; Zhu, Runqi1,3,4; Huang, Xin3,4; Xu, Huae2; Li, Yaping3,4,6,7,8; Yin, Qi3,4,5
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2022-12-01
页码14
ISSN号1616-301X
关键词calcitriol DiR docetaxel nanoparticles red blood cell membranes
DOI10.1002/adfm.202212109
通讯作者Xu, Huae(xuhuae@njmu.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) ; Yin, Qi(qyin@simm.ac.cn)
英文摘要The red blood cell membrane (RBCm) provides tight protection, lowers the immunogenicity, and prolongs the circulation time of drugs in vivo when acting as the coating of drug delivery systems. However, the cellular uptake and release of drugs are hindered by RBCm. Docetaxel (DTX) is the first-line medicine for treating triple-negative breast cancer (TNBC), but it induces tumor metastasis. To solve these dilemmas, in this study, the photosensitizer 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR)-modified RBCm (DM) is prepared, which is coated onto a hybrid micelle consisting of the prodrugs of DTX and the anti-metastasis agent calcitriol (CTL), obtaining a nanoparticle, named HDC-DM. In a 4T1 tumor-bearing mouse model, after injecting HDC-DM, the intratumoral DTX and CTL concentrations are increased by 1.7 and 2.5 times compared with the free drug groups. After irradiating tumors with near-infrared laser, DiR elicits the photothermal effect, triggering the rupture of RBCm and drug release, promoting drug penetration in tumors, and inducing immunogenic cell death. The tumor growth inhibition rate is 77%, and the formation of lung metastases is reduced by 82%, with good biocompatibility. It is suggested that the combination of phototherapy, chemotherapy, and anti-metastatic therapy using HDC-DM is expected to be a powerful strategy for treating TNBC.
WOS关键词CANCER
资助项目National Natural Science Foundation of China[81 871 471] ; National Natural Science Foundation of China[31 930 066] ; National Natural Science Foundation of China[32 171 315] ; National Natural Science Foundation of China[32 130 058] ; National Natural Science Foundation of China[82 073 308] ; International Partnership Program of CAS[153631KYSB20190013] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Postdoctoral Innovation Project of Shandong Province[202 101 019] ; High-level Startup Fund of Nanjing Medical University[KY109RC2019010] ; Key Project of Connotation Construction of Nanjing Medical University
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000916634500001
源URL[http://119.78.100.183/handle/2S10ELR8/303657]  
专题新药研究国家重点实验室
通讯作者Xu, Huae; Li, Yaping; Yin, Qi
作者单位1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
2.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
7.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
8.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Ting,Lang, Tianqun,Zheng, Chao,et al. Promote Intratumoral Drug Release and Penetration to Counteract Docetaxel-Induced Metastasis by Photosensitizer-Modified Red Blood Cell Membrane-Coated Nanoparticle[J]. ADVANCED FUNCTIONAL MATERIALS,2022:14.
APA Wu, Ting.,Lang, Tianqun.,Zheng, Chao.,Yan, Wenlu.,Li, Yu.,...&Yin, Qi.(2022).Promote Intratumoral Drug Release and Penetration to Counteract Docetaxel-Induced Metastasis by Photosensitizer-Modified Red Blood Cell Membrane-Coated Nanoparticle.ADVANCED FUNCTIONAL MATERIALS,14.
MLA Wu, Ting,et al."Promote Intratumoral Drug Release and Penetration to Counteract Docetaxel-Induced Metastasis by Photosensitizer-Modified Red Blood Cell Membrane-Coated Nanoparticle".ADVANCED FUNCTIONAL MATERIALS (2022):14.

入库方式： OAI收割

来源：上海药物研究所

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