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Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa

文献类型：期刊论文

作者Xu, Ting1,2; Zhao, Qing-Min1,2; Yao, Li-Gong1; Lan, Le-Fu1,2; Li, Song-Wei3,4; Guo, Yue-Wei1,2,5,6
刊名STEROIDS
出版日期2023-04-01
卷号192页码:5
关键词Soft coral Sinularia depressa Oxygenated steroids Antibacterial activity
ISSN号0039-128X
DOI10.1016/j.steroids.2023.109182
通讯作者Lan, Le-Fu() ; Li, Song-Wei() ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Four new steroids, namely sinulasterols D-G (1-4), along with seven known related ones 5-11, were isolated from the Xisha soft coral Sinularia depressa. The structures of the new compounds were elucidated by a combi-nation of extensive spectroscopic analyses, chemical conversion method, and comparison of the NMR data with those of known analogues. In in vitro bioassays, compounds 1-3 showed significant antibacterial activities against gram-positive bacteria Enterococcus faecium with minimum inhibitory concentration (MIC) values of 62.5, 125, and 125 mu M, respectively, comparable with that of vancomycin (MIC: >44.2 mu M).
WOS关键词POLYHYDROXYLATED STEROIDS ; SPONGE
资助项目National Nat- ural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000921156900001
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/303663]  
专题新药研究国家重点实验室
通讯作者Lan, Le-Fu; Li, Song-Wei; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China
4.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
6.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Ting,Zhao, Qing-Min,Yao, Li-Gong,et al. Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa[J]. STEROIDS,2023,192:5.
APA Xu, Ting,Zhao, Qing-Min,Yao, Li-Gong,Lan, Le-Fu,Li, Song-Wei,&Guo, Yue-Wei.(2023).Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa.STEROIDS,192,5.
MLA Xu, Ting,et al."Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa".STEROIDS 192(2023):5.

入库方式： OAI收割

来源：上海药物研究所

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