Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa
文献类型:期刊论文
作者 | Xu, Ting1,2; Zhao, Qing-Min1,2; Yao, Li-Gong1; Lan, Le-Fu1,2; Li, Song-Wei3,4; Guo, Yue-Wei1,2,5,6 |
刊名 | STEROIDS |
出版日期 | 2023-04-01 |
卷号 | 192页码:5 |
ISSN号 | 0039-128X |
关键词 | Soft coral Sinularia depressa Oxygenated steroids Antibacterial activity |
DOI | 10.1016/j.steroids.2023.109182 |
通讯作者 | Lan, Le-Fu() ; Li, Song-Wei() ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
英文摘要 | Four new steroids, namely sinulasterols D-G (1-4), along with seven known related ones 5-11, were isolated from the Xisha soft coral Sinularia depressa. The structures of the new compounds were elucidated by a combi-nation of extensive spectroscopic analyses, chemical conversion method, and comparison of the NMR data with those of known analogues. In in vitro bioassays, compounds 1-3 showed significant antibacterial activities against gram-positive bacteria Enterococcus faecium with minimum inhibitory concentration (MIC) values of 62.5, 125, and 125 mu M, respectively, comparable with that of vancomycin (MIC: >44.2 mu M). |
WOS关键词 | POLYHYDROXYLATED STEROIDS ; SPONGE |
资助项目 | National Nat- ural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000921156900001 |
源URL | [http://119.78.100.183/handle/2S10ELR8/303663] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Lan, Le-Fu; Li, Song-Wei; Guo, Yue-Wei |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China 4.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 6.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Ting,Zhao, Qing-Min,Yao, Li-Gong,et al. Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa[J]. STEROIDS,2023,192:5. |
APA | Xu, Ting,Zhao, Qing-Min,Yao, Li-Gong,Lan, Le-Fu,Li, Song-Wei,&Guo, Yue-Wei.(2023).Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa.STEROIDS,192,5. |
MLA | Xu, Ting,et al."Sinulasterols D-G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa".STEROIDS 192(2023):5. |
入库方式: OAI收割
来源:上海药物研究所
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