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Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413

文献类型：期刊论文

作者Ye, Yuxiu1; Liang, Jiaqi2; She, Jianglian2; Lin, Xiuping2; Wang, Junfeng2; Liu, Yonghong1,2; Yang, Dehua3; Tan, Yanhui4; Luo, Xiaowei1; Zhou, Xuefeng1,2
刊名MARINE DRUGS
出版日期2023
卷号21期号:1页码:11
关键词sponge-derived fungus Penicillium sp PI3K NF-kappa B
DOI10.3390/md21010027
通讯作者Tan, Yanhui(tyh533@126.com) ; Luo, Xiaowei(luoxiaowei1991@126.com) ; Zhou, Xuefeng(xfzhou@scsio.ac.cn)
英文摘要Marine sponge-derived fungi have been proven to be a prolific source of bioactive natural products. Two new alkaloids, polonimides E (1) and D (2), and a new butenolide derivative, eutypoid F (11), were isolated from the Beibu Gulf sponge-derived fungus, Penicillium sp. SCSIO 41413, together with thirteen known compounds (3-10, 12-16). Their structures were determined by detailed NMR, MS spectroscopic analyses, and electronic circular dichroism (ECD) analyses. Butenolide derivatives 11 and 12 exhibited inhibitory effect against the enzyme PI3K with IC50 values of 1.7 mu M and 9.8 mu M, respectively. The molecular docking was also performed to understand the inhibitory activity, while 11 and 12 showed obvious protein/ligand-binding effects to the PI3K protein. Moreover, 4 and 15 displayed obvious inhibitory activity against LPS-induced NF-kappa B activation in RAW264.7 cells at 10 mu M.
WOS关键词QUINAZOLINE ALKALOIDS
资助项目National Natural Science Foundation of China[U20A20101] ; National Natural Science Foundation of China[81973235] ; National Natural Science Foundation of China[82260692] ; National Natural Science Foundation of China[82104496] ; Guangdong Local Innovation Team Program[2019BT02Y262] ; Guangzhou Science and Technology Project[202102080478] ; Special Fund for Bagui Scholars of Guangxi ; K. C. Wong Education Foundation[GJTD-2020-12]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000920313700001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/303675]  
专题中国科学院上海药物研究所
通讯作者Tan, Yanhui; Luo, Xiaowei; Zhou, Xuefeng
作者单位1.Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
4.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541001, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Yuxiu,Liang, Jiaqi,She, Jianglian,et al. Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413[J]. MARINE DRUGS,2023,21(1):11.
APA Ye, Yuxiu.,Liang, Jiaqi.,She, Jianglian.,Lin, Xiuping.,Wang, Junfeng.,...&Zhou, Xuefeng.(2023).Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413.MARINE DRUGS,21(1),11.
MLA Ye, Yuxiu,et al."Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413".MARINE DRUGS 21.1(2023):11.

入库方式： OAI收割

来源：上海药物研究所

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