Fluorescent "AND " logic gates for simultaneous detection of thiols and protons: photophysical properties, mechanism and bioimaging of living cells
文献类型：期刊论文
| 作者 | Zhou, Langping1; Yu, Zhihao1; Zhang, Guangzhu1; Jin, Zechen1,2; Zhang, Weibing1; Qian, Junhong1 |
| 刊名 | ANALYTICAL METHODS
 |
| 出版日期 | 2023-02-09 |
| 卷号 | 15期号:6页码:818-828 |
| ISSN号 | 1759-9660 |
| DOI | 10.1039/d2ay01742c |
| 通讯作者 | Zhang, Weibing(weibingzhang@ecust.edu.cn) ; Qian, Junhong(junhongqian@ecust.edu.cn) |
| 英文摘要 | Five fluorescent probes TP1-5 were demonstrated as two-input "AND " molecular logic gates for the detection of thiols and protons. The molecules were designed based on "thiol receptor-spacer(1)-fluorophore-spacer(2)-proton receptor " mode. The logic gates were constructed by employing maleimide, naphthalimide and morpholine (TP1-3)/N-methyl piperazine (TP4-5) as the thiol receptor, fluorophore and proton receptor, respectively. All probes show significant fluorescence enhancements upon addition of both protons and thiols. However, much weaker spectral responses were observed with the addition of only one single analyte. The fluorescence outputs, based on photoinduced electron transfer (PET) and (twisted) intramolecular charge transfer (TICT/ICT), were modulated by the proton receptor and linker. The length of spacer(1) affects the responses toward thiols, whereas spacer(2) influences the sensing performance toward protons. The difference between the pK(a) values of morpholine (similar to 5.80) and N-methyl piperazine (similar to 7.10) enables us to detect thiols in divergent pH circumstances. TP1-3 exhibit an excellent "AND " logic function for simultaneous detection of protons and thiols as well as bioimaging thiols in weakly acidic living cells. However, TP4 and TP5 are not good candidates for executing "AND " logic operation possibly due to the stronger electron donating properties and steric effect of N-methyl piperazine. |
| WOS关键词 | PROBE ; PH ; PEROXYNITRITE ; GLUTATHIONE |
| 资助项目 | NSFC[21974045] |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Spectroscopy |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000920202600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303705]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Weibing; Qian, Junhong |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Langping,Yu, Zhihao,Zhang, Guangzhu,et al. Fluorescent "AND " logic gates for simultaneous detection of thiols and protons: photophysical properties, mechanism and bioimaging of living cells[J]. ANALYTICAL METHODS,2023,15(6):818-828. |
| APA | Zhou, Langping,Yu, Zhihao,Zhang, Guangzhu,Jin, Zechen,Zhang, Weibing,&Qian, Junhong.(2023).Fluorescent "AND " logic gates for simultaneous detection of thiols and protons: photophysical properties, mechanism and bioimaging of living cells.ANALYTICAL METHODS,15(6),818-828. |
| MLA | Zhou, Langping,et al."Fluorescent "AND " logic gates for simultaneous detection of thiols and protons: photophysical properties, mechanism and bioimaging of living cells".ANALYTICAL METHODS 15.6(2023):818-828. |
入库方式： OAI收割
来源：上海药物研究所
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