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Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry

文献类型：期刊论文

作者Yi, Wenzhe2,3; Xiao, Ping2,3; Liu, Xiaochen2,3; Zhao, Zitong2,3; Sun, Xiangshi2,3; Wang, Jue2,3; Zhou, Lei2,3; Wang, Guanru2,3; Cao, Haiqiang2,3; Wang, Dangge1,2,3
刊名SIGNAL TRANSDUCTION AND TARGETED THERAPY
出版日期2022-12-02
卷号7期号:1页码:25
ISSN号2095-9907
DOI10.1038/s41392-022-01250-1
通讯作者Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic engineering, bioorthogonal groups can be tagged onto cell membranes, which selectively attach to cargos with paired groups via bioorthogonal reactions. Due to its simplicity, high efficiency, and specificity, bioorthogonal chemistry has demonstrated great application potential in drug delivery. On the one hand, bioorthogonal reactions improve therapeutic agent delivery to target sites, overcoming off-target distribution. On the other hand, nanoparticles and biomolecules can be linked to cell membranes by bioorthogonal reactions, providing approaches to developing multi-functional drug delivery systems (DDSs). In this review, we first describe the principle of labeling cells or pathogenic microorganisms with bioorthogonal groups. We then highlight recent breakthroughs in developing active targeting DDSs to tumors, immune systems, or bacteria by bioorthogonal chemistry, as well as applications of bioorthogonal chemistry in developing functional bio-inspired DDSs (biomimetic DDSs, cell-based DDSs, bacteria-based and phage-based DDSs) and hydrogels. Finally, we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug delivery. We expect this review will help us understand the latest advances in the development of active targeting and multi-functional DDSs using bioorthogonal chemistry and inspire innovative applications of bioorthogonal chemistry in developing smart DDSs for disease treatment.
WOS关键词ANTIGEN-PRESENTING CELLS ; FREE CLICK CHEMISTRY ; IN-VIVO ; SYNTHETIC BIOLOGY ; SYNERGISTIC THERAPY ; AMINO-ACIDS ; STEM-CELLS ; T-CELLS ; CANCER ; NANOPARTICLES
资助项目National Natural Science Foundation of China ; Strategic Priority Research Program of CAS ; Youth Innovation Promotion Association of CAS ; [81903548] ; [32170935] ; [32070927] ; [81690265] ; [XDA12050307] ; [2019283]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000911803100001
源URL[http://119.78.100.183/handle/2S10ELR8/303793]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China
推荐引用方式
GB/T 7714		 Yi, Wenzhe,Xiao, Ping,Liu, Xiaochen,et al. Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2022,7(1):25.
APA Yi, Wenzhe.,Xiao, Ping.,Liu, Xiaochen.,Zhao, Zitong.,Sun, Xiangshi.,...&Li, Yaping.(2022).Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry.SIGNAL TRANSDUCTION AND TARGETED THERAPY,7(1),25.
MLA Yi, Wenzhe,et al."Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry".SIGNAL TRANSDUCTION AND TARGETED THERAPY 7.1(2022):25.

入库方式： OAI收割

来源：上海药物研究所

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