Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer
文献类型：期刊论文
| 作者 | Chen, Fangmin2,3; Li, Tianliang2; Zhang, Huijuan2; Saeed, Madiha2; Liu, Xiaoying2; Huang, Lujia2,3; Wang, Xiyuan2; Gao, Jing2; Hou, Bo2; Lai, Yi2 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2023-01-10 |
| 页码 | 15 |
| ISSN号 | 0935-9648 |
| 关键词 | acid-ionizable nanoadjuvants cancer vaccines iron oxide nanoparticles personalized immunotherapy STING cascade activation |
| DOI | 10.1002/adma.202209910 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | The critical challenge for cancer vaccine-induced T-cell immunity is the sustained activation of antigen cross-presentation in antigen-presenting cells (APCs) with innate immune stimulation. In this study, it is first discovered that the clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment the type-I interferon (IFN-I) production profile of the stimulator of interferon genes (STING) agonist MSA-2 and achieve a 16-fold dosage-sparing effect in the human STING haplotype. Acid-ionizable copolymers are coassembled with IONPs and MSA-2 into iron nanoadjuvants to concentrate STING activation in the draining lymph nodes. The top candidate iron nanoadjuvant (PEIM) efficiently delivers the model antigen ovalbumin (OVA) to CD169+ APCs and facilitates antigen cross-presentation to elicit a 55-fold greater frequency of antigen-specific CD8(+) cytotoxic T-lymphocyte response than soluble antigen. PEIM@OVA nanovaccine immunization induces potent and durable antitumor immunity to prevent tumor lung metastasis and eliminate established tumors. Moreover, PEIM nanoadjuvant is applicable to deliver autologous tumor antigen and synergizes with immune checkpoint blockade therapy for prevention of postoperative tumor recurrence and distant metastasis in B16-OVA melanoma and MC38 colorectal tumor models. The acid-ionizable iron nanoadjuvant offers a generalizable and readily translatable strategy to augment STING cascade activation and antigen cross-presentation for personalized cancer vaccination immunotherapy. |
| WOS关键词 | OXIDE NANOPARTICLES ; NANOVACCINE ; DELIVERY ; VACCINES ; PATHWAY ; DNA |
| 资助项目 | Major Project of the Study on Pathogenesis and Epidemic Prevention Technology System by the Ministry of Science and Technology of China[2021YFC2302500] ; National Natural Science Foundation of China[U22A20328] ; National Natural Science Foundation of China[52111530092] ; National Natural Science Foundation of China[32050410287] ; Science and Technology Commission of Shanghai Municipality[20430711800] ; China Postdoctoral Science Foundation[2021M00157] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences[2021424] ; National Facility for Protein Science in Shanghai (NFPS), Shanghai Advanced Research Institute, CAS ; Shanghai Institute of Materia Medica, CAS[2021-09-YHJ-06] ; Shanghai Institute of Materia Medica, CAS[2022-09-YHJ-07] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000911366000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303811]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200241, Peoples R China 5.Fudan Univ, Childrens Hosp, Inst Biomed Sci, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fangmin,Li, Tianliang,Zhang, Huijuan,et al. Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer[J]. ADVANCED MATERIALS,2023:15. |
| APA | Chen, Fangmin.,Li, Tianliang.,Zhang, Huijuan.,Saeed, Madiha.,Liu, Xiaoying.,...&Yu, Haijun.(2023).Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer.ADVANCED MATERIALS,15. |
| MLA | Chen, Fangmin,et al."Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer".ADVANCED MATERIALS (2023):15. |
入库方式： OAI收割
来源：上海药物研究所
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