Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy
文献类型：期刊论文
| 作者 | Zheng, Ziliang2; Chen, Xuejiao2; Dai, Rong2; Wu, Shutong2; Kang, Weiwei2; Qin, YuFei2; Ren, Shilei3; Zhang, Ruiping2; Cheng, Zhen1 |
| 刊名 | MATERIALS TODAY BIO
 |
| 出版日期 | 2022-12-15 |
| 卷号 | 17页码:10 |
| ISSN号 | 2590-0064 |
| 关键词 | Second near -infrared window Dual -modal imaging Activatable NIR-II FL Imaging Tumor hypoxia Synergistic tumor therapy |
| DOI | 10.1016/j.mtbio.2022.100478 |
| 通讯作者 | Zhang, Ruiping(zrp_7142@sxmu.edu.cn) |
| 英文摘要 | Tumor microenvironment (TME)-activated theranostics is a promising strategy to effectively identify small le-sions, improve antitumor efficacy, and reduce the risk of undesired side effects. Hypoxia, as a common charac-teristic of TME, can serve as a preferred site for stimulus-dependent activation; however, tumor-hypoxia levels in various developmental stages exhibit different characteristics, severely limiting the response sensitivity. Herein, a circulating self-reinforcing hypoxic nanoamplifier (CGH NAs) is developed that utilizes a dual-chain reaction process (internal regulation, internal regulation) to achieve precise activation of NIR-II FL/photoacoustic (PA) imaging-guided synergistic therapy. Inspired by the positive correlation of nitroreductase (NTR) with hypoxia, the CGH NAs encapsulate CQ4T and GOx into NTR-sensitive hyaluronic acid-nitroimidazole (HA-NI) shell via a self-assembly approach, enabling aggregation-caused NIR-II FL quenching and tumor-accurate delivery. When CGH NAs efficiently accumulated in the tumor region, the intensive local NTR reduced hydrophobic -NO2 to hydro-philic -NH2, which lead to disassembly of CGH NAs. The released GOx could consume O2 (internal regulation) and glucose to cut off the energy supply, inducing tumor-starvation therapy; generate gluconic acid and H2O2 (oxidative stress). Meanwhile, the released CQ4T promoted rapid recovery of NIR-II FL signals for imaging-guided PDT, which could simultaneously deplete intratumoral O2 (external stimulation). Remarkably, the strengthened tumor-hypoxia levels in turn accelerated the NTR-responsive degradation of the CGH NAs, thereby achieving high-efficiency theranostic. |
| WOS关键词 | PHOTODYNAMIC THERAPY |
| 资助项目 | National Natural Science Foundation of China[82102124] ; National Natural Science Foundation of China[82071987] ; National Natural Science Foundation of China[81771907] ; National Natural Science Foundation of China[8211001138] ; National Natural Science Foundation of China[8210072688] ; Science and technology innovation team project of Shanxi Province[201705D131026] ; Engineering Technology Research Center of Shanxi Province[201805D121008] ; Scientific and technological achievements transformation project of Shanxi Province[201704D131006] ; Laboratory Construction Project of Shanxi Province ; Projects for Local Science and Technology Development Guided by the Central Committee[YDZX20191400002537] ; Shanxi Schol-arship Council of China[2020-177] ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province[20200006] ; Four Batches of Scientific Research Projects of Shanxi Pro-vincial Health Commission[2020TD11] ; Four Batches of Scientific Research Projects of Shanxi Pro-vincial Health Commission[2020SYS15] ; Four Batches of Scientific Research Projects of Shanxi Pro-vincial Health Commission[2020XM10] ; KeyLaboratory of Nano-imaging and Drug-loaded Preparation of Shanxi Province[202104010910010] ; Shanxi Province Science Foundation for Youths[201901D211343] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000908044500006 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303820]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Ruiping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanxi Med Univ, Dept Radiol, Hosp 1, Taiyuan 030001, Peoples R China 3.North Univ China, Sch Informat & Commun Engn, Informat & Commun Engn, Taiyuan 030051, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Ziliang,Chen, Xuejiao,Dai, Rong,et al. Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy[J]. MATERIALS TODAY BIO,2022,17:10. |
| APA | Zheng, Ziliang.,Chen, Xuejiao.,Dai, Rong.,Wu, Shutong.,Kang, Weiwei.,...&Cheng, Zhen.(2022).Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy.MATERIALS TODAY BIO,17,10. |
| MLA | Zheng, Ziliang,et al."Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy".MATERIALS TODAY BIO 17(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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