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Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster

文献类型：期刊论文

作者Zhang, Ya-Nan3,4; Zhang, Hong-Qing1,4; Wang, Gui-Feng5; Zhang, Zhe-Rui4; Li, Jia-Qi1,4; Chen, Xiao-Ling1,4; Hu, Yan-Yan1,4; Zeng, Xiang-Yue1,4; Shi, Yu-Jia2; Wang, Jing1,4
刊名ANTIVIRAL RESEARCH
出版日期2023
卷号209页码:9
ISSN号0166-3542
关键词Omicron VEEV VRP Replicable mRNA
DOI10.1016/j.antiviral.2022.105507
通讯作者Wang, Chun-He(wangc@simm.ac.cn) ; Zhu, Bing(zhubing@gzhmu.edu.cn) ; Zhang, Bo(zhangbo@wh.iov.cn)
英文摘要The Omicron variant is sweeping the world, which displays striking immune escape potential through mutations at key antigenic sites on the spike protein, making broad-spectrum SARS-CoV-2 prevention or therapeutical strategies urgently needed. Previously, we have reported a hACE2-targeting neutralizing antibody 3E8, which could efficiently block both prototype SARS-CoV-2 and Delta variant infections in prophylactic mouse models, having the potential of broad-spectrum to prevent SARS-CoV-2. However, preparation of monoclonal neutral-izing antibodies is severely limited by the time-consuming process and the relative high cost. Here, we utilized a modified VEEV replicon with two subgenomic (sg) promoters engineered to express the light and heavy chains of the 3E8 mAb. The feasibility and protective efficacy of replicating mRNA encoding 3E8 against Omicron infection in the hamster were demonstrated through the lung targeting delivery with the help of VEEV-VRP. Overall, we developed a safe and cost-effective platform of broad-spectrum to prevent SARS-CoV-2 infection.
WOS关键词VARIANT
资助项目National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; [32200132] ; [2022M720895]
WOS研究方向Pharmacology & Pharmacy ; Virology
语种英语
出版者ELSEVIER
WOS记录号WOS:000910681600001
源URL[http://119.78.100.183/handle/2S10ELR8/303884]  
专题中国科学院上海药物研究所
通讯作者Wang, Chun-He; Zhu, Bing; Zhang, Bo
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Hunan Normal Univ, Sch Med, Changsha 410081, Peoples R China
3.Guangzhou Med Univ, Inst Pediat, Ctr Lab, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Peoples R China
4.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China
5.Shanghai Inst Mat Med, Biotherapeut Discovery Res Ctr, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ya-Nan,Zhang, Hong-Qing,Wang, Gui-Feng,et al. Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster[J]. ANTIVIRAL RESEARCH,2023,209:9.
APA Zhang, Ya-Nan.,Zhang, Hong-Qing.,Wang, Gui-Feng.,Zhang, Zhe-Rui.,Li, Jia-Qi.,...&Zhang, Bo.(2023).Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster.ANTIVIRAL RESEARCH,209,9.
MLA Zhang, Ya-Nan,et al."Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster".ANTIVIRAL RESEARCH 209(2023):9.

入库方式： OAI收割

来源：上海药物研究所

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