Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities
文献类型：期刊论文
| 作者 | Zhou, Bin1,2; Gao, Xin-Hua1; Zhang, Min -Min1; Liu, Hong-Chun1,2 ; Yue, Jian-Min1,2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2022-12-30 |
| 页码 | 13 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.2c00971 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Continued efforts to expand the structural diversity of dichapetalins and explore further the cytotoxic structure- activity relationships have led to the isolation of 17 undescribed analogues, dichapelonins A-Q (1-17 ), and three known compounds (18-20) from the twigs of Dichapetalum longipetalum. Compounds 1-17 comprise five compound classes as classified by varied C6-C2 conjugates at the A ring of the 13,30-cyclo-dammarane skeleton, and their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallography. Biological tests revealed compounds 1-7 with a phenyl-butadiene appendage to be the most potent cytotoxic compound type of those evaluated. |
| WOS关键词 | CONSTITUENTS |
| 资助项目 | National Natural Science Foundation[22007095] ; Youth Innovation Promotion Association of CAS[2022283] ; Shanghai Pujiang Program[21PJ1416000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000907774700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303911]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Gao, Xin-Hua,Zhang, Min -Min,et al. Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities[J]. JOURNAL OF NATURAL PRODUCTS,2022:13. |
| APA | Zhou, Bin,Gao, Xin-Hua,Zhang, Min -Min,Liu, Hong-Chun,&Yue, Jian-Min.(2022).Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities.JOURNAL OF NATURAL PRODUCTS,13. |
| MLA | Zhou, Bin,et al."Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities".JOURNAL OF NATURAL PRODUCTS (2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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