Copper-catalyzed multicomponent assembly of gamma-butenolides via the interception of carbonyl ylides with iminium ions
文献类型：期刊论文
| 作者 | Zhang, Mengchu2; Yu, Sifan2; Hua, Ruyu2; Zhang, Dan1,2; Qiu, Huang2; Hu, Wenhao2 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2022-12-20 |
| 页码 | 6 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d2ob02075k |
| 通讯作者 | Zhang, Dan(zhangdan5@mail.sysu.edu.cn) ; Qiu, Huang(qiuhuang@mail.sysu.edu.cn) ; Hu, Wenhao(huwh9@mail.sysu.edu.cn) |
| 英文摘要 | A Cu(i)-catalyzed three-component reaction of cyclopropenes, enamines and aldehydes has been realized. This reaction proceeds via the interception of carbonyl oxonium ylide intermediates with alpha, beta-unsaturated iminium ions that are in situ generated from enamines and aldehydes under the catalysis of Cu(MeCN)(4)PF6, leading to the desired gamma-butenolide derivatives in good yields and with moderate diastereoselectivities. Access to these derivatives with tethered ketone and alkynal groups will expand the structural diversity of multi-substituted butenolides. |
| WOS关键词 | STEREOSELECTIVE-SYNTHESIS ; COOPERATIVE CATALYSIS ; 3-COMPONENT REACTIONS ; CYCLOPROPENES ; CYCLOISOMERIZATION ; CYCLOPROPANATION ; ALKYLIDENEBUTENOLIDES ; REARRANGEMENT ; MECHANISM ; INSERTION |
| 资助项目 | National Natural Science Foundation of China[81973176] ; National Natural Science Foundation of China[21901259] ; National Natural Science Foundation of China[22171294] ; National Natural Science Foundation of China[92056201] ; Guangdong Innovative and Entrepreneurial Research Team Program[2016ZT06Y337] ; Guangdong Provincial Key Laboratory of Chiral Molecule ; Natural Science Foundation of Guangdong Province[2021A1515010401] ; Natural Science Foundation of Guangdong Province[2019B030301005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000906472900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304025]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Dan; Qiu, Huang; Hu, Wenhao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Sun Yat sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Mengchu,Yu, Sifan,Hua, Ruyu,et al. Copper-catalyzed multicomponent assembly of gamma-butenolides via the interception of carbonyl ylides with iminium ions[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2022:6. |
| APA | Zhang, Mengchu,Yu, Sifan,Hua, Ruyu,Zhang, Dan,Qiu, Huang,&Hu, Wenhao.(2022).Copper-catalyzed multicomponent assembly of gamma-butenolides via the interception of carbonyl ylides with iminium ions.ORGANIC & BIOMOLECULAR CHEMISTRY,6. |
| MLA | Zhang, Mengchu,et al."Copper-catalyzed multicomponent assembly of gamma-butenolides via the interception of carbonyl ylides with iminium ions".ORGANIC & BIOMOLECULAR CHEMISTRY (2022):6. |
入库方式： OAI收割
来源：上海药物研究所
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