Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics
文献类型：期刊论文
| 作者 | An, Ruibing3; Liu, Lingjun1,2; Wei, Shixuan3; Huang, Zheng3; Qiu, Ling4; Lin, Jianguo4; Liu, Hong1,2 ; Ye, Deju3
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| 刊名 | ACS NANO
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| 出版日期 | 2022-12-27 |
| 卷号 | 16期号:12页码:20607-20621 |
| ISSN号 | 1936-0851 |
| 关键词 | coassembly disassembly imaging synergistic therapy glioma |
| DOI | 10.1021/acsnano.2c07491 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Ye, Deju(dejuye@nju.edu.cn) |
| 英文摘要 | Controlling delivery and release of therapeutic agents to accomplish on-demand synergistic therapy of orthotopic gliomas is desired but challenging. Here, we report a glioma targeting and redox activatable theranostic nanoprobe (Co-NP-RGD1/1) for magnetic resonance (MR) and fluores-cence (FL) bimodal imaging-guided on-demand synergistic chemotherapy/photodynamic therapy (Chemo-PDT) of ortho-topic gliomas. Co-NP-RGD1/1 is formed via molecular coassembly of two paramagnetic and fluorogenic small -molecule probes CPT-RGD and PPa-RGD at an optimized molar ratio of 1/1, which shows a high longitudinal relaxivity (r1 = 17.0 +/- 0.6 mM-1 s-1, 0.5 T) but weak FL emissions and low Chemo-PDT activity. Upon reduction by endogenous glutathione (GSH), Co-NP-RGD1/1 disassemble and release small molecules 2-RGD, chemodrug camptothecin (CPT), and near-infrared (NIR) photosensitizer (PS) PPa-SH that further binds to endogenous albumin to form PPa-SH-albumin complex, allowing to turn on FL, chemotherapeutic efficacy, and PDT activity for synergistic Chemo-PDT of orthotopic U87MG or U251 gliomas in living mice. Moreover, Co-NP-RGD1/1 can also allow noninvasive detection and monitoring of orthotopic brain tumor growth via FL and MR imaging. Findings suggest the potential of cascade coassembly and stimuli -controlled intracellular disassembly strategy for constructing targeted and activatable nanoagents for improving combinational cancer theranostics. |
| WOS关键词 | GLIOBLASTOMA ; COMBINATION ; RADIATION ; THERAPY ; CAMPTOTHECIN ; ANGIOGENESIS ; TEMOZOLOMIDE ; STRATEGY ; DELIVERY |
| 资助项目 | National Key R&D Program of China ; National Natural Science Founda-tion of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Excellent Research Program of Nanjing University ; China Postdoctoral Science Foundation ; [2021YFA0910003] ; [21922406] ; [21775071] ; [21632008] ; [82130105] ; [22137003] ; [BK20190055] ; [BK20202004] ; [020514380251] ; [ZYJH004] ; [2021M701654] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000906044400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304028]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Ye, Deju |
| 作者单位 | 1.China Pharmaceut Univ, Dept Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ, State Key Lab Analyt Chem Life Sci, Chem & Biomed Innovat Ctr ChemBIC, Sch Chem & Chem Engn, Nanjing 210023, Peoples R China 4.Jiangsu Inst Nucl Med, NHC Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Wuxi 214063, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Ruibing,Liu, Lingjun,Wei, Shixuan,et al. Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics[J]. ACS NANO,2022,16(12):20607-20621. |
| APA | An, Ruibing.,Liu, Lingjun.,Wei, Shixuan.,Huang, Zheng.,Qiu, Ling.,...&Ye, Deju.(2022).Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics.ACS NANO,16(12),20607-20621. |
| MLA | An, Ruibing,et al."Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics".ACS NANO 16.12(2022):20607-20621. |
入库方式： OAI收割
来源：上海药物研究所
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