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Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties

文献类型：期刊论文

作者Du, Ye-Qing1,2; Liang, Lin-Fu3; Guo, Yue-Wei1,2,4,5
刊名CHEMISTRY & BIODIVERSITY
出版日期2022-12-30
页码20
关键词Cladiella diterpenoids steroids cytotoxicity anti-inflammatory activity
ISSN号1612-1872
DOI10.1002/cbdv.202201065
通讯作者Liang, Lin-Fu(lianglinfu@csuft.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Marine octocorals belonging to the genus Cladiella, usually encountered on reefs in the Indo-Pacific region, have been proven to be rich sources of diverse secondary metabolites with intriguing structural features and promising bioactivities. In this review, 155 compounds from six unambiguously identified C. krempfi, C. australis, C. pachyclados, C. hirsuta, C. tuberculosa, C. conifera, together with several unidentified Cladiella spp. are summarized covering the literatures from 2006 to August 2022. It is noteworthy that diterpenoids dominated the secondary metabolite profile of this genus counting for 78 %. Structurally, the majority of these diterpenes belonged to eunicellan family characterized by different patterns of ether linkage. The impacts of these chemical compositions on an array of potential pharmacological activities were also reviewed, giving an overview of the potential application of Cladiella secondary metabolites.
WOS关键词EUNICELLIN-BASED DITERPENOIDS ; SOFT CORALS ; A-D ; DISCOVERY
资助项目National Natural Science Foundation of China (NSFC) ; National Key Research and Development Program of China ; SKLDR/SIMM Project ; [81991521] ; [41876194] ; [2022YFC2804100] ; [SIMM2103ZZ-06]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000905227500001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/304034]  
专题新药研究国家重点实验室
通讯作者Liang, Lin-Fu; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
5.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Du, Ye-Qing,Liang, Lin-Fu,Guo, Yue-Wei. Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties[J]. CHEMISTRY & BIODIVERSITY,2022:20.
APA Du, Ye-Qing,Liang, Lin-Fu,&Guo, Yue-Wei.(2022).Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties.CHEMISTRY & BIODIVERSITY,20.
MLA Du, Ye-Qing,et al."Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties".CHEMISTRY & BIODIVERSITY (2022):20.

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来源：上海药物研究所

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