Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2
文献类型：期刊论文
| 作者 | Choi, Pyeong Seok4; Lee, Jun Young4; Chae, Jung Ho4; Wadas, Thaddeus1; Cheng, Zhen2; Hur, Min Goo3; Park, Jeong Hoon4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2022-12-27 |
| 页码 | 10 |
| 关键词 | Cherenkov radiation Zr-89 TiO2 MnO2 transferrin nanocomposite reactive oxygen species |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.2c09195 |
| 通讯作者 | Park, Jeong Hoon(parkjh@kaeri.re.kr) |
| 英文摘要 | Cherenkov radiation (CR) derived from the decay of diagnostic and therapeutic radionuclides is currently being studied by the scientific community to determine if these emissions can be harnessed for cancer detection and therapy. While Cherenkov luminescence imaging (CLI) has been studied in the preclinical and clinical settings, Cherenkov radiation-induced cancer therapy (CRICT) is a relatively new area of research that harnesses the emitted photons to kill cancer cells through free radical generation and DNA damage. Nanoparticles seem well suited for developing a theranostic platform that would allow researchers to visualize therapy delivery and also generate the reactive oxygen species necessary to kill cancer cells. Herein, we report the preparation of an 89Zr-TiO2- MnO2 nanocomposite that incorporates transferrin onto the nanoparticle surface to enhance cancer cell growth inhibition. The incorporation of the positron emission tomography (PET) radioisotope 89Zr (half-life: 3.3 days) allowed for the detection of the nanoparticle using PET and for the creation of Cherenkov emissions that interacted with the nanoparticle surface to generate free radicals for therapy delivery. After preparation, these systems were observed to be stable in various media and provided excellent tumor growth control after being intratumorally injected into mice bearing CT-26 tumors. These results demonstrate that a therapeutically efficient CRICT platform can be generated using commercially available and affordable materials. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; CERENKOV RADIATION ; NANOPARTICLES ; CANCER |
| 资助项目 | Korea Atomic Energy Research Institute ; National Research Foundation - Korean Government[2017M2A2A6A05016600] ; National Research Foundation - Korean Government[2021M2E7A1079112] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000906442300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304037]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Park, Jeong Hoon |
| 作者单位 | 1.Univ Iowa, Carver Coll Med, Dept Radiol, Iowa City, IA 52242 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Korea Atom Energy Res Inst, Radiat Utilizat & Facil, Management Div, Jeongeup Si 56212, Jeollabuk Do, South Korea 4.Korea Atom Energy Res Inst, Accelerator Radioisotope Dev Team, Jeongeup Si 56212, Jeollabuk Do, South Korea |
| 推荐引用方式 GB/T 7714 | Choi, Pyeong Seok,Lee, Jun Young,Chae, Jung Ho,et al. Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2[J]. ACS APPLIED MATERIALS & INTERFACES,2022:10. |
| APA | Choi, Pyeong Seok.,Lee, Jun Young.,Chae, Jung Ho.,Wadas, Thaddeus.,Cheng, Zhen.,...&Park, Jeong Hoon.(2022).Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2.ACS APPLIED MATERIALS & INTERFACES,10. |
| MLA | Choi, Pyeong Seok,et al."Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2".ACS APPLIED MATERIALS & INTERFACES (2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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