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Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy

文献类型：期刊论文

作者Qian, Xindi1,2,6; Wang, Yuqi1,2; Xie, Honglei5; Wang, Chen5; Li, Jie1,2; Lei, Ying7; Liu, Huanzhen7; Wu, Yao3,4; Li, Yaping1,2; Zhang, Zhiwen3,4,5
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2023
卷号353页码:447-461
ISSN号0168-3659
关键词Radiotherapy Oxaliplatin Nitric oxide Peroxynitrite Spatiotemporal distribution
DOI10.1016/j.jconrel.2022.11.044
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The spatiotemporal distribution of therapeutic agents in tumors remains an essential challenge of radiationmediated therapy. Herein, we rationally designed a macrophage microvesicle-inspired nanovehicle of nitric oxide donor-oxaliplatin (FO) conjugate (M-PFO), aiming to promote intratumor permeation and distribution profiles for chemo-radiotherapy. FO was responsively released from M-PFO in intracellular acidic environments, and then be activated by glutathione (GSH) into active oxaliplatin and NO molecules in a programmed manner. M-PFO exhibited notable accumulation, permeation and cancer cell accessibility in tumor tissues. Upon radiation, the reactive peroxynitrite species (ONOO-) were largely produced, which could diffuse into regions over 400 mu m away from the tumor vessels and be detectable after 24 h of radiation, thereby exhibiting superior efficacy in improving the spatiotemporal distribution in tumors versus common reactive oxygen species (ROS). Moreover, M-PFO mediated chemo-radiotherapy caused notable inhibition of tumor growth, with an 89.45% inhibition in HT-29 tumor models and a 92.69% suppression in CT-26 tumor models. Therefore, this bioinspired design provides an encouraging platform to improve intratumor spatiotemporal distribution to synergize chemoradiotherapy.
WOS关键词LUNG METASTASIS ; RADIOTHERAPY ; GLUTATHIONE ; MICROENVIRONMENT ; MECHANISMS ; DIFFUSION ; NITROGEN
资助项目National Key R & D Program of China[2022YFC3401400] ; National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[32271461] ; National Natural Science Foundation of China[32130058]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000905303100001
源URL[http://119.78.100.183/handle/2S10ELR8/304043]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
4.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Qian, Xindi,Wang, Yuqi,Xie, Honglei,et al. Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2023,353:447-461.
APA Qian, Xindi.,Wang, Yuqi.,Xie, Honglei.,Wang, Chen.,Li, Jie.,...&Zhang, Zhiwen.(2023).Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy.JOURNAL OF CONTROLLED RELEASE,353,447-461.
MLA Qian, Xindi,et al."Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy".JOURNAL OF CONTROLLED RELEASE 353(2023):447-461.

入库方式： OAI收割

来源：上海药物研究所

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