Targeting glycolysis for cancer therapy using drug delivery systems
文献类型：期刊论文
| 作者 | Huang, Yongzhuo1,2,3
|
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2023 |
| 卷号 | 353页码:650-662 |
| 关键词 | Glycolysis cancer metabolism Immunotherapy Tumor microenvironment Nanomedicine Targeted drug delivery |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2022.12.003 |
| 通讯作者 | Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | There is close crosstalk between cancer metabolism and immunity. Cancer metabolism regulation is a promising therapeutic target for cancer immunotherapy. Warburg effect is characterized by abnormal glucose metabolism that includes common features of increased glucose uptake and lactate production. The aerobic glycolysis can reprogram the cancer cells and promote the formation of a suppressive immune microenvironment. As a case in point, lactate plays an essential role in tumorigenesis, which is the end product of glycolysis as well as serves as a fuel supporting cancer cell survival. Meanwhile, it is also an important immune regulator that drives immuno-suppression in tumors. Immunometabolic therapy is to intervene tumor metabolism and regulate the related metabolites that participate in the innate and acquired immunity, thereby reinstalling the immune balance and eliciting anticancer immune responses. In this contribution to the Orations - New Horizons of the Journal of controlled Release I will provide an overview of glucose metabolism in tumors and its effects on drug resistance and tumor metastasis, and present the advance of glycolysis-targeting therapy strategies with drug delivery techniques, as well as discuss the challenges in glycolysis-targeting immunometabolic therapy. |
| WOS关键词 | GROWTH-FACTOR RECEPTOR ; T-CELL ; MEDIATED INHIBITION ; AEROBIC GLYCOLYSIS ; ANTITUMOR IMMUNITY ; TUMOR-GROWTH ; METASTASIS ; BREAST ; EXPRESSION ; ANGIOGENESIS |
| 资助项目 | National Key Research and Development Program of China, China[2021YFC2400600] ; National Key Research and Development Program of China, China[2021YFE0103100] ; Project of High-level New R D Institute[2019B090904008] ; National Natural Science Foundation of China[81925035] ; High-level Innovative Research Institute from Department of Science and Technology of Guangdong Province, China[2021B0909050003] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000906688400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304046]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.501 Hai ke Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, SIMM, Zhongshan Inst Drug Discovery, Zhongshan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yongzhuo. Targeting glycolysis for cancer therapy using drug delivery systems[J]. JOURNAL OF CONTROLLED RELEASE,2023,353:650-662. |
| APA | Huang, Yongzhuo.(2023).Targeting glycolysis for cancer therapy using drug delivery systems.JOURNAL OF CONTROLLED RELEASE,353,650-662. |
| MLA | Huang, Yongzhuo."Targeting glycolysis for cancer therapy using drug delivery systems".JOURNAL OF CONTROLLED RELEASE 353(2023):650-662. |
入库方式： OAI收割
来源：上海药物研究所
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