Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging
文献类型：期刊论文
| 作者 | Wang, Shichao6; Shi, Hui2,3,4; Wang, Lushun6; Loredo, Axel6; Bachilo, Sergei M.6; Wu, William6; Tian, Zeru6; Chen, Yuda6; Weisman, R. Bruce6; Zhang, Xuanjun1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2022-12-28 |
| 卷号 | 144期号:51页码:23668-23676 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.2c11223 |
| 通讯作者 | Cheng, Zhen(zcheng@simm.ac.cn) ; Xiao, Han(han.xiao@rice.edu) |
| 英文摘要 | The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF2) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF2 formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF2 formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies. |
| WOS关键词 | MODALITY MRI ; SURGERY ; DELIVERY ; TUMORS |
| 资助项目 | Cancer Prevention Research Institute of Texas (CPRIT)[RR170014] ; NIH[R35-GM133706] ; NIH[R21-CA255894] ; U.S. Department of Defense[W81XWH-21-1-0789] ; Robert A. Welch Foundation[C-1970] ; Robert A. Welch Foundation[C-0807] ; National Science Foundation[CHE-1803066] ; National Science Foundation[CHE-2203309] ; Hamill Innovation Award (Hamill Foundation) ; John S. Dunn Foundation Collaborative Research Award (Gulf Coast Consortia) ; Department of Radiology, Stanford University |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000907252700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304049]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen; Xiao, Han |
| 作者单位 | 1.Univ Macau, Fac Hlth Sci, MOE Frontiers Sci Ctr Precis Oncol, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Stanford Univ, Dept Radiol, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA 4.Stanford Univ, Biox Program, Stanford, CA 94305 USA 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 6.Rice Univ, Dept Chem, Houston, TX 77005 USA 7.Rice Univ, Dept Biosci, Dept Bioengn, Houston, TX 77005 USA |
| 推荐引用方式 GB/T 7714 | Wang, Shichao,Shi, Hui,Wang, Lushun,et al. Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2022,144(51):23668-23676. |
| APA | Wang, Shichao.,Shi, Hui.,Wang, Lushun.,Loredo, Axel.,Bachilo, Sergei M..,...&Xiao, Han.(2022).Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,144(51),23668-23676. |
| MLA | Wang, Shichao,et al."Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144.51(2022):23668-23676. |
入库方式： OAI收割
来源：上海药物研究所
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