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Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora

文献类型：期刊论文

作者Chen, Shu-Shuai1; Tong, Xiao2; Liu, Xiang-Yu1; Zheng, Cheng-Yu2; Zhou, Jun-Su2; Fan, Yao-Yue2; He, Shi-Jun3; Zhou, Bin2; Yue, Jian-Min1
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2022-12-14
页码7
ISSN号0022-3263
DOI10.1021/acs.joc.2c02442
通讯作者Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Baccaramiones A-D (1-4), four highly oxygenated and rearranged trinorditerpenoids, were isolated from Baccaurea ramiflora. Compound 1 is a 1(10-* 5)-abeo-15,16,17-trinor-ent- abietane featuring a unique 5/6/6 spirocyclic scaffold, and 2-4 are the first example of a novel 20(10-* 5)-abeo-15,16,17-trinor-ent- abietane skeleton. Their structures were established by spectroscopic analysis, X-ray crystallography, and electronic circular dichroism calculations. A plausible biosynthetic pathway for 1-4 was proposed. Interestingly, compounds 3 and 4 exhibited significant immunosuppressive activities against concanavalin A induced T cell proliferation and lipopolysaccharide-induced B cell proliferation in vitro.
资助项目National Natural Science Foundation[22177122] ; Youth Innovation Promotion Association of CAS[21PJ1416000] ; Shanghai Pujiang Program[2022283] ; Shanghai Jiao Tong University[22177122] ; Xishuangbanna Tropical Botanical Garden ; Chinese Academy of Sciences, People's Republic of China, ; [SMECD2022006]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000898911300001
源URL[http://119.78.100.183/handle/2S10ELR8/304165]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin; Yue, Jian-Min
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Jiangsu 210023, Nanjing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shu-Shuai,Tong, Xiao,Liu, Xiang-Yu,et al. Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora[J]. JOURNAL OF ORGANIC CHEMISTRY,2022:7.
APA Chen, Shu-Shuai.,Tong, Xiao.,Liu, Xiang-Yu.,Zheng, Cheng-Yu.,Zhou, Jun-Su.,...&Yue, Jian-Min.(2022).Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora.JOURNAL OF ORGANIC CHEMISTRY,7.
MLA Chen, Shu-Shuai,et al."Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora".JOURNAL OF ORGANIC CHEMISTRY (2022):7.

入库方式： OAI收割

来源：上海药物研究所

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