Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale
文献类型：期刊论文
| 作者 | Fan, Yao-Yue1,2,3; Zheng, Cheng-Yu1,3; Zhou, Bin1,2,3; Zimbres, Flavia M. M.4; Cassera, Maria B. B.4; Yue, Jian-Min1,2,3
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2022-12-23 |
| 页码 | 7 |
| 关键词 | Natural products C-25 Terpenoids Structure elucidation Biosynthetic pathway hypothesis Antimalarial activity |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202200597 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Chemical investigation of Hedyosmum orientale led to the identification of two terpenoid derivatives, dyosmunoids A and B (1 and 2) featuring two different 3/5/6/6/5-fused pentacyclic ring systems, respectively. Compound 1 is the second natural product of this C-25 terpenoid compound class, and compound 2 is a rare dinor-C-25 terpenoid with a peroxide bridge. Their structural elucidation was achieved by the comprehensive analysis of spectroscopic data, single-crystal X-ray diffraction, and ECD calculation. Putative biosynthetic pathways for compounds 1 and 2 are proposed. Compound 2 exhibited strong antimalarial activity with an IC50 value of 0.42 mu mol.L-1. |
| WOS关键词 | PLASMODIUM-FALCIPARUM ; SESQUITERPENOIDS ; MALARIA |
| 资助项目 | National Natural Science Foundation of China[82122062] ; National Natural Science Foundation of China[81861138045] ; National Natural Science Foundation of China[22177121] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program (CAS)[KFJ-BRP-008] ; Science and Technology Commission of Shanghai Municipality[20ZR1467800] ; Youth Innovation Promotion Association CAS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000903350200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304186]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China 4.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Dept Biochem & Mol Biol, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Fan, Yao-Yue,Zheng, Cheng-Yu,Zhou, Bin,et al. Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale[J]. CHINESE JOURNAL OF CHEMISTRY,2022:7. |
| APA | Fan, Yao-Yue,Zheng, Cheng-Yu,Zhou, Bin,Zimbres, Flavia M. M.,Cassera, Maria B. B.,&Yue, Jian-Min.(2022).Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale.CHINESE JOURNAL OF CHEMISTRY,7. |
| MLA | Fan, Yao-Yue,et al."Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale".CHINESE JOURNAL OF CHEMISTRY (2022):7. |
入库方式： OAI收割
来源：上海药物研究所
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