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Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri

文献类型：期刊论文

作者Yang, Yue1,2; Zhou, Fei3; Wang, Min2,4; Turanazarov, Mukhammadrizo2,4; Wang, Xiao-Rong5; Ke, Changqiang1,2; Yao, Sheng1,2; Lin, Ligen3; Tang, Chunping1,2; Ye, Yang1,2,4,6
刊名MOLECULES
出版日期2022-12-01
卷号27期号:23页码:18
关键词Tacca chantrieri structural elucidation withanolides chantriolides F-P hepatoprotective effect
DOI10.3390/molecules27238197
通讯作者Tang, Chunping(tangcp@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn)
英文摘要Eleven highly oxidized withanolides, chantriolides F-P (1-11), together with six known analogues (12-17), were isolated from the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were further confirmed by experimental ECD data and single crystal X-ray diffraction analysis. The structures of compounds 5-8 contained a chlorine atom substituted at C-3. Compounds 1 and 12 are a pair of epimers isomerized at C-24 and C-25, while compounds 9 and 16 are isomerized at C-1, C-7, C-24, and C-25. Next, the hepatoprotective effect of all the isolates was evaluated on tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes. Compounds 5-11 and 16 significantly enhanced cell viability. Compound 8 decreased reactive oxygen species accumulation and increased glutathione level in t-BHP injured AML12 hepatocytes through promoting nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).
WOS关键词RHIZOMES ; NRF2 ; GLUCOSIDES ; LIVER ; TACCALONOLIDES ; INJURY
资助项目National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China[21920102003] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[81872754] ; University of Macau[MYRG2020-00091-ICMS] ; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau[QRCM-IRG2022-014]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000897346500001
源URL[http://119.78.100.183/handle/2S10ELR8/304189]  
专题新药研究国家重点实验室
通讯作者Tang, Chunping; Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Xishuangbanna Hosp Tradit Dai Med, Xishuangbanna Res Inst Nationality Med, 8 Zhuangdong Western Rd Xishuangbanna Tourism & R, Xishuangbanna 666100, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yue,Zhou, Fei,Wang, Min,et al. Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri[J]. MOLECULES,2022,27(23):18.
APA Yang, Yue.,Zhou, Fei.,Wang, Min.,Turanazarov, Mukhammadrizo.,Wang, Xiao-Rong.,...&Ye, Yang.(2022).Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri.MOLECULES,27(23),18.
MLA Yang, Yue,et al."Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri".MOLECULES 27.23(2022):18.

入库方式： OAI收割

来源：上海药物研究所

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