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Macrophage Membrane-Coated Nano- Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function

文献类型：期刊论文

作者Li, Jie2,3,4; Wu, Yao1,2,3,5; Wang, Jiaoying2,3; Xu, Xiaoxuan2,3; Zhang, Ao6; Li, Yaping2,3,7; Zhang, Zhiwen1,5
刊名ACS NANO
出版日期2022-12-16
页码15
关键词gemcitabine macrophage nanoparticle lymphocytes infiltration immunotherapy
ISSN号1936-0851
DOI10.1021/acsnano.2c07861
通讯作者Zhang, Ao(ao6919zhang@sjtu.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The limited lymphocyte infiltration and exhaus-tion of tumoricidal functions in solid tumors remain a formidable obstacle to cancer immunotherapy. Herein, we designed a macrophage membrane-coated nano-gemcitabine system (MNGs) to promote lymphocyte infiltration and then synergized anti-programmed death ligand 1 (antiPD-L1) to reinvigorate the exhausted lymphocytes. MNGs exhibited effective intratumor-permeating and responsive drug-releasing capacity, produced notable elimination of versatile immuno-suppressive cells, and promoted lymphocyte infiltration into cancer cell regions in tumors, but over 50% of these infiltrated lymphocytes were in the exhausted state. Compared with MNG monotherapy, the MNGs+antiPD-L1 combination produced 31.77% and 30.63% reduction of exhausted CD3+CD8+ T cells and natural triller (NK) cells and 2.83-and 3.17-fold increases of interferon-gamma (IFN-gamma)-positive subtypes, respectively, thereby resulting in considerable therapeutic benefits in several tumor models. Thus, MNGs provide an encouraging strategy to promote lymphocyte infiltration and synergize antiPD-L1 to restore their tumoricidal function for cancer immunotherapy.
WOS关键词LUNG METASTASIS ; T-CELL ; CANCER ; TUMORS ; CHEMOTHERAPY ; PH
资助项目National Key R&D Program of China ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation of China ; Key scientific research program of CAS ; China Postdoctoral Science Foundation ; Shanghai Postdoctoral Excellence Program ; [2022YFC3401400] ; [32071385] ; [32271461] ; [32130058] ; [ZR2019ZD25] ; [QYZDJ-SSW-SMC020] ; [2021M693271] ; [2020496]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000901604600001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/304195]  
专题新药研究国家重点实验室
通讯作者Zhang, Ao; Li, Yaping; Zhang, Zhiwen
作者单位1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai, Shandong, Peoples R China
5.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
7.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jie,Wu, Yao,Wang, Jiaoying,et al. Macrophage Membrane-Coated Nano- Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function[J]. ACS NANO,2022:15.
APA Li, Jie.,Wu, Yao.,Wang, Jiaoying.,Xu, Xiaoxuan.,Zhang, Ao.,...&Zhang, Zhiwen.(2022).Macrophage Membrane-Coated Nano- Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function.ACS NANO,15.
MLA Li, Jie,et al."Macrophage Membrane-Coated Nano- Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function".ACS NANO (2022):15.

入库方式： OAI收割

来源：上海药物研究所

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