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CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice

文献类型：期刊论文

作者Tan, Rongrong1,2; Li, Jiayang1; Liu, Lu2; Wu, Qian2; Fan, Lei2,3; Ma, Ningning2,4; Yu, Chuwei2,3; Lu, Henglei2; Zhang, Xuemei1; Chen, Jing2,3
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2022-12-01
卷号23期号:24页码:14
关键词NAFLD CSAD obesity liver damage fatty acid beta-oxidation mitochondrial damage
DOI10.3390/ijms232415931
通讯作者Zhang, Xuemei(xuemzhang@fudan.edu.cn) ; Ren, Jin(jren@cdser.simm.ac.cn)
英文摘要Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic disease manifested in hepatic steatosis, inflammation, fibrosis, etc., which affects over one-quarter of the population around the world. Since no effective therapeutic drugs are available to cope with this widespread epidemic, the functional research of genes with altered expression during NAFLD helps understand the pathogenesis of this disease and the development of new potential therapeutic targets for drugs. In the current work, we discovered via the analysis of the Gene Expression Omnibus (GEO) dataset that cysteine sulfinic acid decarboxylase (CSAD) decreased significantly in NAFLD patients, which was also confirmed in multiple NAFLD mouse models (HFD-fed C57BL/6J, db/db and HFHFrHC-fed C57BL/6J mice). Next, CSAD's function in the progression of NAFLD was explored using AAV-mediated liver-directed gene overexpression in an HFD-fed mouse model, where the overexpression of CSAD in the liver could alleviate NAFLD-associated pathologies, including body weight, liver/body weight ratio, hepatic triglyceride and total cholesterol, and the degree of steatosis. Mechanically, we found that the overexpression of CSAD could increase the expression of some genes related to fatty acid beta-oxidation (Acad1, Ppara, and Acox1). Furthermore, we also detected that CSAD could improve mitochondrial injury in vitro and in vivo. Finally, we proposed that the effect of CSAD on lipid accumulation might be independent of the taurine pathway. In conclusion, we demonstrated that CSAD is involved in the development of NAFLD as a protective factor, which suggested that CSAD has the potential to become a new target for drug discovery in NAFLD.
WOS关键词LIVER-DISEASE NAFLD ; INSULIN-RESISTANCE ; MECHANISMS ; EXPRESSION ; DIAGNOSIS ; TAURINE ; SCORE
资助项目Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine ; Foundation of Shanghai Science and Technology Committee ; [ZYYCXTD-D-202210] ; [21DZ2291100]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000901246100001
源URL[http://119.78.100.183/handle/2S10ELR8/304198]  
专题新药研究国家重点实验室
通讯作者Zhang, Xuemei; Ren, Jin
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmacol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Rongrong,Li, Jiayang,Liu, Lu,et al. CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(24):14.
APA Tan, Rongrong.,Li, Jiayang.,Liu, Lu.,Wu, Qian.,Fan, Lei.,...&Ren, Jin.(2022).CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(24),14.
MLA Tan, Rongrong,et al."CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.24(2022):14.

入库方式： OAI收割

来源：上海药物研究所

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