Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin
文献类型：期刊论文
| 作者 | Liu, Peng2; Ye, Lichun3; Ren, Yongshen2; Zhao, Guodun1,4; Zhang, Yun1,4; Lu, Shaojuan5; Li, Qiang2; Wu, Chen2; Bai, Lijie2; Zhang, Zhongyun2 |
| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2022-12-26 |
| 页码 | 16 |
| ISSN号 | 0007-1188 |
| 关键词 | aescin GBP5 NLRP3 inflammasome phlebitis vinorelbine |
| DOI | 10.1111/bph.16002 |
| 通讯作者 | Lan, Zhou(lzlz_84@163.com) ; Feng, Jing(fengjing@simm.ac.cn) ; Chen, Lvyi(clyhappy05@163.com) |
| 英文摘要 | Background and PurposeIntravenous infusion of chemotherapy drugs can cause severe chemotherapy-induced phlebitis (CIP) in patients. However, the underlying mechanism of CIP development remains unclear. Experimental ApproachRNA-sequencing analysis was used to identify potential disease targets in CIP. Guanylate binding protein-5 (GBP5) genetic deletion approaches also were used to investigate the role of GBP5 in NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in lipopolysaccharide (LPS) primed murine bone-marrow-derived macrophages (BMDMs) induced by vinorelbine (VIN) in vitro and in mouse models of VIN-induced CIP in vivo. The anti-CIP effect of aescin was evaluated, both in vivo and in vivo. Key ResultsHere, we show that the expression of GBP5 was upregulated in human peripheral blood mononuclear cells from CIP patients. Genetic ablation of GBP5 in murine macrophages significantly alleviated VIN-induced CIP in the experimental mouse model. Mechanistically, GBP5 contributed to the inflammatory responses through activating NLRP3 inflammasome and driving the production of the inflammatory cytokine IL-1 beta. Moreover, aescin, a mixture of triterpene saponins extracted from horse chestnut seed, can alleviate CIP by inhibiting the GBP5/NLRP3 axis. Conclusion and ImplicationsThese findings suggest that GBP5 is an important regulator of NLRP3 inflammasome in CIP mouse model. Our work further reveals that aescin may serve as a promising candidate in the clinical treatment of CIP. |
| WOS关键词 | GUANYLATE-BINDING PROTEINS ; NLRP3 INFLAMMASOME ; CONCISE GUIDE ; PHARMACOLOGY ; INFUSION ; VINORELBINE ; IMMUNITY ; CANCER ; THROMBOPHLEBITIS ; EPIRUBICIN |
| 资助项目 | National Natural Science Foundation of China[81873221] ; National Natural Science Foundation of China[82074081] ; National Natural Science Foundation of China[82171214] ; Knowledge Innovation Program of Wuhan-Basic Research[2022020801010404] ; Special Fund for the Basic Scientific Research of Central Colleges, South-Central Minzu University[CZP20003] ; Special Fund for the Basic Scientific Research of Central Colleges, South-Central Minzu University[CZY20024] ; Distinguished Young Scholars of Hubei University of Chinese Medicine[2022ZZXJ005] ; Lingang Laboratory[LG-QS-202203-07] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000904025800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304204]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lan, Zhou; Feng, Jing; Chen, Lvyi |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan, Peoples R China 3.Hubei Univ Chinese Med, Sch Pharm, Wuhan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai, Peoples R China 5.Tongji Univ, Sch Med, Shanghai, Peoples R China 6.Washington Univ, Ctr Study Itch, Dept Anesthesiol, Sch Med, St Louis, MO USA 7.Barnes Jewish Hosp, St Louis, MO USA |
| 推荐引用方式 GB/T 7714 | Liu, Peng,Ye, Lichun,Ren, Yongshen,et al. Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin[J]. BRITISH JOURNAL OF PHARMACOLOGY,2022:16. |
| APA | Liu, Peng.,Ye, Lichun.,Ren, Yongshen.,Zhao, Guodun.,Zhang, Yun.,...&Chen, Lvyi.(2022).Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin.BRITISH JOURNAL OF PHARMACOLOGY,16. |
| MLA | Liu, Peng,et al."Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin".BRITISH JOURNAL OF PHARMACOLOGY (2022):16. |
入库方式： OAI收割
来源：上海药物研究所
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