Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
文献类型：期刊论文
| 作者 | Liu, Yameng1; Zhong, Xianchun1,2; Lin, Suqin3; Xu, Hualing3; Liang, Xinyu3; Wang, Yibin1,4; Xu, Jingyi3; Wang, Kanglong1; Guo, Xiaozhen1; Wang, Jiawen5,6 |
| 刊名 | MICROBIOME
 |
| 出版日期 | 2022-12-15 |
| 卷号 | 10期号:1页码:22 |
| ISSN号 | 2049-2618 |
| 关键词 | Obesity Prebiotic Probiotics Short-chain fatty acids Propionate Thermogenesis Browning |
| DOI | 10.1186/s40168-022-01430-9 |
| 通讯作者 | Xie, Cen(xiecen@simm.ac.cn) |
| 英文摘要 | Objective: High intake of caffeoylquinic acid (CQA)-rich dietary supplements, such as green coffee bean extracts, offers health-promoting effects on maintaining metabolic homeostasis. Similar to many active herbal ingredients with high pharmacological activities but low bioavailability, CQA has been reported as a promising thermogenic agent with anti-obesity properties, which contrasts with its poor oral absorption. Intestinal tract is the first site of CQA exposure and gut microbes might react quickly to CQA. Thus, it is of interest to explore the role of gut microbiome and microbial metabolites in the beneficial effects of CQA on obesity-related disorders. Results: Oral CQA supplementation effectively enhanced energy expenditure by activating browning of adipose and thus ameliorated obesity-related metabolic dysfunctions in high fat diet-induced obese (DIO) mice. Here, 16S rRNA gene amplicon sequencing revealed that CQA treatment remodeled the gut microbiota to promote its anti-obesity actions, as confirmed by antibiotic treatment and fecal microbiota transplantation. CQA enriched the gut commensal species Limosilactobacillus reuteri (L. reuteri) and stimulated the production of short-chain fatty acids, especially propionate. Mono-colonization of L. reuteri or low-dose CQA treatment did not reduce adiposity in DIO mice, while their combination elicited an enhanced thermogenic response, indicating the synergistic effects of CQA and L. reuteri on obesity. Exogenous propionate supplementation mimicked the anti-obesity effects of CQA alone or when combined with L. reuteri, which was ablated by the monocarboxylate transporter (MCT) inhibitor 7ACC1 or MCT1 disruption in inguinal white adipose tissues to block propionate transport. Conclusions: Our data demonstrate a functional axis among L. reuteri, propionate, and beige fat tissue in the anti-obesity action of CQA through the regulation of thermogenesis. These findings provide mechanistic insights into the therapeutic use of herbal ingredients with poor bioavailability via their interaction with the gut microbiota. |
| WOS关键词 | CHAIN FATTY-ACIDS ; CHLOROGENIC ACID ; GUT MICROBIOTA ; COFFEE ; METABOLISM ; TRANSPLANTATION ; PROPIONATE ; RESISTANCE ; RELEASE ; INDEXES |
| 资助项目 | National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[2021YFA1301200] ; National Natural Science Foundation of China[XDB39020600] ; China Postdoctoral Science Foundation[82222071] ; China Postdoctoral Science Foundation[82104261] ; China Postdoctoral Science Foundation[82173873] ; Project supported by Shanghai Municipal Science and Technology Major Project[2020M671269] |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| 出版者 | BMC |
| WOS记录号 | WOS:000899317200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304216]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Cen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 6.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yameng,Zhong, Xianchun,Lin, Suqin,et al. Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders[J]. MICROBIOME,2022,10(1):22. |
| APA | Liu, Yameng.,Zhong, Xianchun.,Lin, Suqin.,Xu, Hualing.,Liang, Xinyu.,...&Xie, Cen.(2022).Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders.MICROBIOME,10(1),22. |
| MLA | Liu, Yameng,et al."Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders".MICROBIOME 10.1(2022):22. |
入库方式： OAI收割
来源：上海药物研究所
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