中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
HBO1 catalyzes lysine benzoylation in mammalian cells

文献类型：期刊论文

作者Tan, Doudou1; Wei, Wei2,3; Han, Zhen4; Ren, Xuelian1; Yan, Cong1; Qi, Shankang1; Song, Xiaohan1; Zheng, Y. George4; Wong, Jiemin2,3; Huang, He1,5
刊名ISCIENCE
出版日期2022-11-18
卷号25期号:11页码:14
DOI10.1016/j.isci.2022.105443
通讯作者Huang, He(hhuang@simm.ac.cn)
英文摘要Lysine benzoylation (Kbz) is a newly discovered protein post-translational modi-fication (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely unknown, hindering further functional studies. Here we identified and validated the lysine acetyltransferase (KAT) HBO1 as a "writer"of Kbz in mammalian cells. In addition, we report the benzoylome in mammalian cells, iden-tifying 1747 Kbz sites; among them at least 77 are the HBO1-targeted Kbz sub-strates. Bioinformatics analysis showed that HBO1-targeted Kbz sites were involved in multiple processes, including chromatin remodeling, transcription regulation, immune regulation, and tumor growth. Our results thus identify the regulatory elements of the Kbz pathway and reveal the non-canonical enzymatic activity and functions of HBO1 in cellular physiology.
WOS关键词METABOLIC-REGULATION ; GENE-EXPRESSION ; REGULATORY ELEMENTS ; ACETYLATION ; ACETYLTRANSFERASES ; BIOLOGY
资助项目National Natural Science Foundation of China[81973164] ; Shanghai Municipal Science and Technology Major Project ; National Science Foundation[1808087]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000892133500010
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/304270]  
专题中国科学院上海药物研究所
通讯作者Huang, He
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China
3.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
4.Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Doudou,Wei, Wei,Han, Zhen,et al. HBO1 catalyzes lysine benzoylation in mammalian cells[J]. ISCIENCE,2022,25(11):14.
APA Tan, Doudou.,Wei, Wei.,Han, Zhen.,Ren, Xuelian.,Yan, Cong.,...&Huang, He.(2022).HBO1 catalyzes lysine benzoylation in mammalian cells.ISCIENCE,25(11),14.
MLA Tan, Doudou,et al."HBO1 catalyzes lysine benzoylation in mammalian cells".ISCIENCE 25.11(2022):14.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。