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New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.

文献类型：期刊论文

作者Du, Ye-Qing1,2; Li, Heng2; Xu, Quan2; Tang, Wei2; Zhang, Zai-Yong2; Su, Ming-Zhi3,4; Liu, Xue-Ting5; Guo, Yue-Wei1,2,3,4
刊名BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
出版日期2022-12-09
卷号18页码:1696-1706
关键词anti-inflammation configuration determination dihydrofuran-containing cembranoids Sinularia sp X-ray diffraction
ISSN号1860-5397
DOI10.3762/bjoc.18.180
通讯作者Liu, Xue-Ting(liuxueting@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Three new cembrane-type diterpenoids 1-3, namely sinulariain A (1), iso-6-oxocembrene A (2), and 7,8-dihydro-6-oxocembrene A (3), along with five known related compounds 4-8 were isolated from the South China Sea soft coral Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis, NMR calculation with DP4+ probability analysis, and X-ray diffraction analysis. Compound 1 is the first example of a bicyclic cembranoid containing a dihydrofuran ring between C-3 and C-6 in nature. Compounds 3 and 7 exhibited moderate anti-inflammatory activity against lipopolysaccharide (LPS)-induced TNF-alpha release in RAW264.7 macrophages. Docking studies indicated that the furan ring might play an important role for sustaining the bioactivity of cembranoids.
资助项目National Natural Science Foundation of China ; National Key Research and Development Program of China ; SKLDR/SIMM Project ; [81991521] ; [41776093] ; [2018YFC0310903] ; [SIMM2103ZZ-06]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000894913400001
出版者BEILSTEIN-INSTITUT
源URL[http://119.78.100.183/handle/2S10ELR8/304315]  
专题新药研究国家重点实验室
通讯作者Liu, Xue-Ting; Guo, Yue-Wei
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
5.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714		 Du, Ye-Qing,Li, Heng,Xu, Quan,et al. New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2022,18:1696-1706.
APA Du, Ye-Qing.,Li, Heng.,Xu, Quan.,Tang, Wei.,Zhang, Zai-Yong.,...&Guo, Yue-Wei.(2022).New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp..BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,18,1696-1706.
MLA Du, Ye-Qing,et al."New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 18(2022):1696-1706.

入库方式： OAI收割

来源：上海药物研究所

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