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cRGD peptide incorporated with patchouli alcohol loaded silk fibroin nanoparticles for enhanced targeting of inflammatory sites in colitis

文献类型：期刊论文

作者Du, Yaoyao2,3,4; Shi, Junyu5; Duan, Ran1,6; Tsim, Karl Wah Keung1,6; Shen, Lan2; Zhang, Ning3; Wang, Bing4
刊名BIOMATERIALS ADVANCES
出版日期2022-09-01
卷号140页码:12
关键词Ulcerative colitis Nanomedicine Cyclo RGD peptide Targeted drug delivery
DOI10.1016/j.bioadv.2022.213069
通讯作者Shen, Lan(alansusu@sina.com) ; Zhang, Ning(ningzh18@126.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要The combination therapy of strengthening inflammation regression and mucosal repair may overcome the "therapeutic ceiling" of ulcerative colitis (UC). However, poor targeting is an outstanding challenge in the preparation of drug delivery systems for UC treatment. Here, we developed anti-inflammatory drug (patchouli alcohol, PA)-loaded nanoparticles (NPs) derived from natural silk fibmin (SF) and subjected to surface functionalization with cyclo RGD peptide (cRGD). Self-assembled SF NPs realized sustained drug release. Meanwhile, cRGD functionalization yielded notably targeted drug delivery to inflamed colon, and thereby enhanced the anti-inflammatory and barrier repair capabilities of NPs. Moreover, cRGD-PASFNs regulated innate immune responses and exerted a potent therapeutic efficacy against acute colitis. Surprisingly, the cRGD-PASFNs also modulated the abnormal level of amino acids which are crucial to the integrity of the intestinal barrier. Additionally, oral delivery of this nanomedicine displayed an excellent safety profile in the mouse model. This study confers confidence for the further development of targeted precision therapy for UC and other inflammatory diseases.
WOS关键词ORAL-DRUG DELIVERY ; BOWEL-DISEASE ; TIGHT JUNCTIONS ; 5-AMINOSALICYLIC ACID ; INTESTINAL BARRIER ; MACROPHAGES ; EFFICACY ; DIET
资助项目Program of Shanghai Committee of Science and Technology, China[21ZR1475200]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000888175800003
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/304392]  
专题中国科学院上海药物研究所
通讯作者Shen, Lan; Zhang, Ning; Wang, Bing
作者单位1.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai 201203, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Natl Clin Res Ctr Oral Dis, Dept Oral & Maxillofacial Implantol,Sch Med, Shanghai, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yaoyao,Shi, Junyu,Duan, Ran,et al. cRGD peptide incorporated with patchouli alcohol loaded silk fibroin nanoparticles for enhanced targeting of inflammatory sites in colitis[J]. BIOMATERIALS ADVANCES,2022,140:12.
APA Du, Yaoyao.,Shi, Junyu.,Duan, Ran.,Tsim, Karl Wah Keung.,Shen, Lan.,...&Wang, Bing.(2022).cRGD peptide incorporated with patchouli alcohol loaded silk fibroin nanoparticles for enhanced targeting of inflammatory sites in colitis.BIOMATERIALS ADVANCES,140,12.
MLA Du, Yaoyao,et al."cRGD peptide incorporated with patchouli alcohol loaded silk fibroin nanoparticles for enhanced targeting of inflammatory sites in colitis".BIOMATERIALS ADVANCES 140(2022):12.

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来源：上海药物研究所

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