TRP channels in inflammatory bowel disease: Potential therapeutic targets
文献类型：期刊论文
| 作者 | Du, Yaoyao1,2; Chen, Jie1,2; Shen, Lan1; Wang, Bing2 |
| 刊名 | BIOCHEMICAL PHARMACOLOGY
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 203页码:13 |
| 关键词 | Transient receptor potential channels Inflammatory bowel diseases Immunomodulatory Research methods |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2022.115195 |
| 通讯作者 | Shen, Lan(alansusu@sina.com) ; Wang, Bing(bwang@simm.ac.cn) |
| 英文摘要 | Given the high rate of nonresponse or resistance to current inflammatory bowel disease (IBD) treatments, novel drug targets and biomarkers that aid in therapeutic prediction are eagerly demanded. Transient receptor potential (TRP) channels are distributed in the gastrointestinal tract (GI) and visceral sensory nervous systems with multiple functions. An upsurge is observed in the amount of research that implicates TRP channels in several physiological and pathological process of IBD, suggesting the therapeutic potential of the TRP channels as drug targets for combating IBD. In this review, we focus on the expression levels and functions of TRP channels in GI and discuss their potential roles in IBD, including neuropeptide modulation, immune response, and the effect of TRP channels on the IBD-related pathological activities, and some experimental methods for TRP, providing theoretical support for future research. |
| WOS关键词 | GENE-RELATED PEPTIDE ; INDUCED CYTOKINE PRODUCTION ; INDUCED INTESTINAL DAMAGE ; MELASTATIN 2 TRPM2 ; SUBSTANCE-P ; ION-CHANNEL ; VISCERAL HYPERALGESIA ; ANKYRIN 1 ; EXPERIMENTAL COLITIS ; VANILLOID 4 |
| 资助项目 | Program of Shanghai Committee of Science and Technology, China[21ZR1475200] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000892111400007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304410]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shen, Lan; Wang, Bing |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Yaoyao,Chen, Jie,Shen, Lan,et al. TRP channels in inflammatory bowel disease: Potential therapeutic targets[J]. BIOCHEMICAL PHARMACOLOGY,2022,203:13. |
| APA | Du, Yaoyao,Chen, Jie,Shen, Lan,&Wang, Bing.(2022).TRP channels in inflammatory bowel disease: Potential therapeutic targets.BIOCHEMICAL PHARMACOLOGY,203,13. |
| MLA | Du, Yaoyao,et al."TRP channels in inflammatory bowel disease: Potential therapeutic targets".BIOCHEMICAL PHARMACOLOGY 203(2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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