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HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis

文献类型：期刊论文

作者Mou, Jiahui1,2; Huang, Meijun3; Wang, Feifei4; Xu, Xiaoding2,5; Xie, Hanqi3; Lu, Henglei2; Li, Mingyang3,6; Li, Yu2; Kong, Weiwen2; Chen, Jing1,2
刊名MOLECULAR CANCER RESEARCH
出版日期2022-12-01
卷号20期号:12页码:1724-1738
ISSN号1541-7786
DOI10.1158/1541-7786.MCR-22-0241
通讯作者Chen, Yiding(ydchen@zju.edu.cn) ; Wang, Chaochen(chaochenwang@intl.zju.edu.cn) ; Ren, Jin(jren@cdser.simm.ac.cn)
英文摘要Cancer progression is highly dependent on the ability of cancer cell tumor formation, in which epigenetic modulation plays an essential role. However, the epigenetic factors promoting breast tumor formation are less known. Screened from three-dimensional (3D)-sphere tumor formation model, HMGN5 that regulates chromatin structures became the candidate therapeutic target in breast cancer, though its role is obscure. HMGN5 is highly expressed in 3D-spheres of breast cancer cells and clinical tumors, also an unfavorable prognostic marker in patients. Furthermore, HMGN5 controls tumor formation and metastasis of breast cancer cells in vitro and in vivo. Mechanistically, HMGN5 is governed by active STAT3 transcriptionally and further escorts STAT3 to shape the oncogenic chromatin land-scape and transcriptional program. More importantly, interfer-ence of HMGN5 by nanovehicle-packaged siRNA effectively inhibits tumor growth in breast cancer cell-derived xenograft mice model.Implications: Our findings reveal a novel feed-forward circuit between HMGN5 and STAT3 in promoting breast cancer tumor-igenesis and suggest HMGN5 as a novel epigenetic therapeutic target in STAT3-hyperactive breast cancer.
WOS关键词BINDING DOMAIN 5 ; GENE-EXPRESSION ; PROMOTES ; PROLIFERATION ; INVASION ; CULTURE ; TUMOR ; ACTIVATION ; RESISTANCE ; PATHWAY
资助项目National Natural Science Foundation of China[2020QN81005] ; Fundamental Research Funds for the Central Universities[SIMM2103ZZ-01] ; Fundamental Research Funds for the State Key Laboratory of Drug Research[21DZ2291100] ; Foundation of Shanghai Science and Technology Committee[ZYYCXTD-D-202210] ; Innovation Team andTalents Cultivation Program of National Administration of Traditional Chinese Medicine ; [31970776]
WOS研究方向Oncology ; Cell Biology
语种英语
出版者AMER ASSOC CANCER RESEARCH
WOS记录号WOS:000892759700001
源URL[http://119.78.100.183/handle/2S10ELR8/304413]  
专题新药研究国家重点实验室
通讯作者Chen, Yiding; Wang, Chaochen; Ren, Jin
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai, Peoples R China
3.Zhejiang Univ, ZJU UoE Inst, Sch Med, Int Campus, Zhejiang, Peoples R China
4.Nanjing Univ Chinese Med, Nanjing, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China
6.Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Breast Surg, Hangzhou, Zhejiang, Peoples R China
7.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Mou, Jiahui,Huang, Meijun,Wang, Feifei,et al. HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis[J]. MOLECULAR CANCER RESEARCH,2022,20(12):1724-1738.
APA Mou, Jiahui.,Huang, Meijun.,Wang, Feifei.,Xu, Xiaoding.,Xie, Hanqi.,...&Ren, Jin.(2022).HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis.MOLECULAR CANCER RESEARCH,20(12),1724-1738.
MLA Mou, Jiahui,et al."HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis".MOLECULAR CANCER RESEARCH 20.12(2022):1724-1738.

入库方式： OAI收割

来源：上海药物研究所

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