Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor
文献类型：期刊论文
| 作者 | Liu, Liyu1,2; Zhang, Zaiyong1; Cheng, Yinxiang1,2; Jiang, Yihua1,2; Lu, Liye1; Wang, Jian-Rong1 ; Mei, Xuefeng1,2
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| 刊名 | CRYSTAL GROWTH & DESIGN
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| 出版日期 | 2022-11-22 |
| 页码 | 13 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/acs.cgd.2c00919 |
| 通讯作者 | Wang, Jian-Rong(xuefengmei@simm.ac.cn) ; Mei, Xuefeng(jrwang@simm.ac.cn) |
| 英文摘要 | L-menthol is one of the most important flavoring additives with abundant plant sources. The distinctive odor, cooling characteristic, and diversified biological activities attribute to its widespread application, especially on confections, oral-care commodities, over-the-counter drugs, and tobacco flavors. However, the manufacturing and storage of L-menthol face challenges due to its high volatility and low melting point. In this work, cocrystallization provides a new strategy to manage the stability problem of this important ingredient. Coformers of dietary sources were chosen based on a supramolecular synthon design, and six cocrystals of L-menthol were synthesized by either a solvent-mediated or solvent-free approach. These new solid forms could significantly increase the melting point and reduce the vapor pressure up to 1/45 of the pure L-menthol. Moreover, cocrystals present a high retention rate under storage conditions. The superior stability can be ascribed to diversified supramolecular cavities assembled by coformers, to which L-menthol molecules are restricted by hydrogen bonds. |
| WOS关键词 | VAPOR-PRESSURE CURVES ; PHARMACEUTICAL COCRYSTALS ; INCLUSION-COMPOUNDS ; CO-CRYSTALS ; ACID ; LIQUID ; ENCAPSULATION ; CYCLODEXTRIN ; SUBLIMATION ; (-)-MENTHOL |
| 资助项目 | Natural Science Foundation of Shanghai ; Shanghai Science and Technology Innovation Action Plan ; [22ZR147390] ; [20142201800] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000889730300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304536]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Jian-Rong; Mei, Xuefeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Liyu,Zhang, Zaiyong,Cheng, Yinxiang,et al. Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor[J]. CRYSTAL GROWTH & DESIGN,2022:13. |
| APA | Liu, Liyu.,Zhang, Zaiyong.,Cheng, Yinxiang.,Jiang, Yihua.,Lu, Liye.,...&Mei, Xuefeng.(2022).Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor.CRYSTAL GROWTH & DESIGN,13. |
| MLA | Liu, Liyu,et al."Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor".CRYSTAL GROWTH & DESIGN (2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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