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Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng.

文献类型：期刊论文

作者Kazymbetova, Aizhan1,2,3; Amangeldi, Magzhan1,2,3; Nurlybekova, Aliya1,4; Amzeyeva, Ulpan1,4; Baktybala, Kunbike1,4; Tang, Chun-Ping3; Ke, Chang-Qiang3; Yao, Sheng3; Ye, Yang2,3; Jenis, Janar1,2,3,4
刊名MOLECULES
出版日期2022-11-01
卷号27期号:22页码:14
关键词Artemisia nitrosa Artemisia marschalliana sesquiterpene lactone coumarin flavonoid phenolic compound cytotoxicity HL-60 A-549
DOI10.3390/molecules27228074
通讯作者Ye, Yang(yye@mail.shcnc.ac.cn) ; Jenis, Janar(janarjenis@kaznu.kz)
英文摘要As a promising source of biologically active substances, the Artemisia species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the Artemisia plants, systematic investigations of two Artemisia species growing in the East Kazakhstan region were conducted. In this study, one new germacrane-type sesquiterpene lactone (11), together with 10 known sesquiterpenes and its dimer, were characterized from A. nitrosa Weber. Additionally, one new chromene derivative (1') with another 12 known compounds, including coumarins, sesquiterpene diketones, phenyl propanoids, polyacetylenics, dihydroxycinnamic acid derivatives, fatty acids, naphthalene derivatives, flavones, and caffeic acid derivatives were isolated from A. marschalliana Spreng. All compounds were isolated and identified for the first time from these two Artemisia species. The structures of new compounds (11, 1') were established by using UV, TOFMS, LC-MS, 1D and 2D NMR spectroscopic analyses. The cytotoxicity of all isolated compounds was evaluated. As a result, all compounds did not show significant inhibition against HL-60 and A-549 cell lines. The sesquiterpenoids isolated from A. nitrosa were tested for their inhibitory activity against the LPS-induced NO release from the RAW624.7 cells, and neither of them exhibited significant activity.
WOS关键词SESQUITERPENE LACTONES ; CHEMICAL-COMPOSITION ; CONSTITUENTS ; EXTRACT ; PLANTS ; GENUS
资助项目Ministry of Education and Science of the Republic of Kazakhstan[AP08856717]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000887456600001
源URL[http://119.78.100.183/handle/2S10ELR8/304539]  
专题新药研究国家重点实验室
通讯作者Ye, Yang; Jenis, Janar
作者单位1.Al Farabi Kazakh Natl Univ, Res Ctr Med Plants, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Res Inst Nat Prod & Technol, Alma Ata 050046, Kazakhstan
推荐引用方式
GB/T 7714		 Kazymbetova, Aizhan,Amangeldi, Magzhan,Nurlybekova, Aliya,et al. Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng.[J]. MOLECULES,2022,27(22):14.
APA Kazymbetova, Aizhan.,Amangeldi, Magzhan.,Nurlybekova, Aliya.,Amzeyeva, Ulpan.,Baktybala, Kunbike.,...&Jenis, Janar.(2022).Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng..MOLECULES,27(22),14.
MLA Kazymbetova, Aizhan,et al."Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng.".MOLECULES 27.22(2022):14.

入库方式： OAI收割

来源：上海药物研究所

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