Elasticity regulates nanomaterial transport as delivery vehicles: Design, characterization, mechanisms and state of the art
文献类型：期刊论文
| 作者 | Nie, Di1,2; Liu, Chang1,2; Yu, Miaorong1,2,3; Jiang, Xiaohe1,2; Wang, Ning1,2; Gan, Yong1,2,3
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 291页码:15 |
| ISSN号 | 0142-9612 |
| 关键词 | Nanomaterial Elasticity Nano-bio interaction Transport Drug delivery |
| DOI | 10.1016/j.biomaterials.2022.121879 |
| 通讯作者 | Gan, Yong(ygan@simm.ac.cn) |
| 英文摘要 | Nanobiotechnology and nanomedicine are rapidly growing fields, in which nanomaterials (NMs) can lead to enhanced therapeutic efficacy by achieving efficient transport and drug delivery in vivo. The physicochemical properties of NMs have a great impact on their interactions with biological environments and hence determine their biological fates and drug delivery efficiency. Despite rapid advances in understanding the significance of NM properties, such as shape, size, and surface charge, there is a pressing need to engineer and discover how elasticity shapes NM transport. Recently, advances in material synthesis and characterization have promoted investigations into the macroscopic roles and microscopic mechanisms of elasticity to modulate nano-bio in-teractions. This review will highlight (1) the basic definitions of elasticity and strategies for modulating NM elasticity; (2) advanced techniques for evaluating the effects of elasticity on nano-bio interactions; (3) the macroscopic role of elasticity in the biological fates of NMs, including blood circulation, biodistribution, bio-logical hydrogel penetration, cellular uptake, and intracellular trafficking; and (4) the potential microscopic mechanisms probed by these advanced characterization techniques. Additionally, challenges and future pros-pects are included. The advanced research discussed in this review will provide guidance to extensively explore the effects and detailed mechanism of elasticity in nano-bio interactions for enhanced drug delivery and developed nanomedicines. |
| WOS关键词 | MEMBRANE-COATED NANOPARTICLES ; ATOMIC-FORCE MICROSCOPY ; PEGYLATED NANOPARTICLES ; HYDROGEL PARTICLES ; STIFFNESS ; DRUG ; SHAPE ; RIGIDITY ; ENDOCYTOSIS ; CIRCULATION |
| 资助项目 | National Science Fund of Distinguished Young Scholars[82025032] ; National Natural Science Foundation of China[82073773] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ-TLC005] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, CAS[SIMM2103ZZ-01] ; Shanghai Municipal Science and Technology Major Project[TM202101L003] ; Major International Joint Research Project of Chinese Academy of Sciences[153631KYSB20190020] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000890425200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304557]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Di,Liu, Chang,Yu, Miaorong,et al. Elasticity regulates nanomaterial transport as delivery vehicles: Design, characterization, mechanisms and state of the art[J]. BIOMATERIALS,2022,291:15. |
| APA | Nie, Di,Liu, Chang,Yu, Miaorong,Jiang, Xiaohe,Wang, Ning,&Gan, Yong.(2022).Elasticity regulates nanomaterial transport as delivery vehicles: Design, characterization, mechanisms and state of the art.BIOMATERIALS,291,15. |
| MLA | Nie, Di,et al."Elasticity regulates nanomaterial transport as delivery vehicles: Design, characterization, mechanisms and state of the art".BIOMATERIALS 291(2022):15. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。