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Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

文献类型：期刊论文

作者Jiang, Lan3,4; Zhang, Tianji5; Lu, Hongzhong6; Li, Saijuan1; Lv, Kangjie4; Tuffour, Alex4; Zhang, Lixin4; Ding, Kan1; Li, Jin-Ping2,7; Li, Hongmei5
刊名SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
出版日期2023-03-01
卷号8期号:1页码:11-19
关键词Heparin Biosynthesis Biological activities Bio-production
ISSN号2405-805X
DOI10.1016/j.synbio.2022.10.002
通讯作者Jiang, Lan(Jianglan@ecust.edu.cn) ; Ding, Kan(dingkan@simm.ac.cn) ; Liu, Xueting(liuxueting@ecust.edu.cn)
英文摘要The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy. Moreover, after more than 2 years, many populations are still under pressure of infection. Thus, a broader perspective in developing antiviral strategies is still of great importance. Inspired by the observed multiple benefits of heparin in the treatment of thrombosis, the potential of low molecular weight heparin (LMWH) for the treatment of COVID-19 have been explored. Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients, accordingly reducing lethality. Furthermore, several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection. These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates. In this review, we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection, focusing on the perspectives of developing heparin mimetics via chemical synthesis, chemoenzymatic synthesis, and bioengineered production by microbial cell factories. The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.
WOS关键词CHEMOENZYMATIC SYNTHESIS ; SULFATE BIOSYNTHESIS ; SUBSTRATE-SPECIFICITY ; LINKAGE REGION ; AMYLOID-BETA ; ZIKA VIRUS ; BINDING ; HEPAROSAN ; HEPARANASE ; RECEPTOR
资助项目National Key Research and Development Program of China ; Swedish research council ; National Natural Science Foundation of China ; [2021YFF0600700] ; [2020YFA090032] ; [2019YFA0906201] ; [2020-05759] ; [31720103901] ; [31961133004] ; [21907031] ; [21977029] ; [22108266]
WOS研究方向Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000889345500001
出版者KEAI PUBLISHING LTD
源URL[http://119.78.100.183/handle/2S10ELR8/304581]  
专题中国科学院上海药物研究所
通讯作者Jiang, Lan; Ding, Kan; Liu, Xueting
作者单位1.Shanghai Inst Mat Med, Chinese Acad Sci, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, Shanghai 201203, Peoples R China
2.Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden
3.Nanjing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Nanjing 210093, Peoples R China
4.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
5.Natl Inst Metrol, Div Chem & Analyt Sci, Key Lab Chem Metrol & Applicat Nutr & Hlth State M, Beijing 100029, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
7.Beijing Univ Chem Technol, Int Res Ctr Soft Matter, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Lan,Zhang, Tianji,Lu, Hongzhong,et al. Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing[J]. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY,2023,8(1):11-19.
APA Jiang, Lan.,Zhang, Tianji.,Lu, Hongzhong.,Li, Saijuan.,Lv, Kangjie.,...&Liu, Xueting.(2023).Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing.SYNTHETIC AND SYSTEMS BIOTECHNOLOGY,8(1),11-19.
MLA Jiang, Lan,et al."Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing".SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 8.1(2023):11-19.

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来源：上海药物研究所

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