A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds
文献类型：期刊论文
| 作者 | He, Guoxue1,2; Li, Yutian1,2; Zhou, Shengbin1,2; Yang, Xiaohao1,2; Shang, Aolong1,2; Wang, Yunbo1,2; Liu, Hong1,2,3 ; Zhou, Yu1,2,3
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| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2022-11-25 |
| 卷号 | 2022期号:44页码:4 |
| 关键词 | Azidation Benzyl C-N bonds C(sp(3))-H Electrochemistry |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.202201041 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn) |
| 英文摘要 | We report a direct azidation of benzylic C(sp(3))-H bonds via an electrochemical process, which use cheap and durable graphite plates as electrodes, without any external oxidants or metal catalysts. This protocol is a novel, green and environmentally benign synthetic strategy to achieve azidation of C(sp(3))-H in benzylic group. More importantly, these azidation products are suitable for late-stage functionalization to afford diversified triazole and tetrazole derivatives. |
| WOS关键词 | METAL-CATALYZED AZIDATION ; C-H BONDS ; CLICK CHEMISTRY ; COUPLING REACTIONS ; AMINATION ; AZOLES ; FUNCTIONALIZATION ; CYCLOADDITION ; SUBSTITUTION ; DIVERSITY |
| 资助项目 | National Natural Science Foundation of China ; Hangzhou innovation and entrepreneurship leading team project ; [82130105] ; [82121005] ; [91953108] ; [TD2020005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000887960000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304659]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Zhou, Yu |
| 作者单位 | 1.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Guoxue,Li, Yutian,Zhou, Shengbin,et al. A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2022,2022(44):4. |
| APA | He, Guoxue.,Li, Yutian.,Zhou, Shengbin.,Yang, Xiaohao.,Shang, Aolong.,...&Zhou, Yu.(2022).A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2022(44),4. |
| MLA | He, Guoxue,et al."A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2022.44(2022):4. |
入库方式： OAI收割
来源：上海药物研究所
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