Smart drug delivery systems for precise cancer therapy
文献类型：期刊论文
| 作者 | Wang, Xiaoyou1; Li, Chong1; Wang, Yiguang2; Chen, Huabing3; Zhang, Xinxin4 ; Luo, Cong5; Zhou, Wenhu6; Li, Lili7; Teng, Lesheng8; Yu, Haijun4
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| 刊名 | ACTA PHARMACEUTICA SINICA B
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| 出版日期 | 2022-11-01 |
| 卷号 | 12期号:11页码:4098-4121 |
| 关键词 | Pharmaceutics Smart drug delivery system Stimuli-responsive Receptor-ligand-based delivery Nano-drug delivery systems Precise therapy Toxicity Cancer |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2022.08.013 |
| 通讯作者 | Li, Chong(chongli@swu.edu.cn) ; Wang, Jiancheng(wang-jc@bjmu.edu.cn) |
| 英文摘要 | Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate bal-ance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibil-ities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomate-rials, and nanotechnology.(c) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS关键词 | STIMULI-RESPONSIVE NANOCARRIERS ; BINDING-SITE BARRIER ; LIPID NANOPARTICLES ; CARRIER-FREE ; PHOTODYNAMIC THERAPY ; CONTROLLED-RELEASE ; CELLULAR UPTAKE ; DNA ORIGAMI ; IN-VITRO ; PH |
| 资助项目 | National Natural Science Foundation of China[81973259] ; National Natural Science Foundation of China[82073789] ; National Natural Science Foundation of China[81803472] ; project for Innovative Research Group at Higher Educational Institutions in Chongqing (China)[CXQT20006] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000882412500005 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304677]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Chong; Wang, Jiancheng |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, Beijing Key Lab Mol Pharmaceut & New Drug Delivery, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 3.Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Dept Pharmaceut, Shenyang 110016, Peoples R China 6.Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China 7.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 8.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoyou,Li, Chong,Wang, Yiguang,et al. Smart drug delivery systems for precise cancer therapy[J]. ACTA PHARMACEUTICA SINICA B,2022,12(11):4098-4121. |
| APA | Wang, Xiaoyou.,Li, Chong.,Wang, Yiguang.,Chen, Huabing.,Zhang, Xinxin.,...&Wang, Jiancheng.(2022).Smart drug delivery systems for precise cancer therapy.ACTA PHARMACEUTICA SINICA B,12(11),4098-4121. |
| MLA | Wang, Xiaoyou,et al."Smart drug delivery systems for precise cancer therapy".ACTA PHARMACEUTICA SINICA B 12.11(2022):4098-4121. |
入库方式： OAI收割
来源：上海药物研究所
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