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A substrate-controlled Ru(ii)-catalyzed C-H activation/[5+2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds

文献类型：期刊论文

作者Zheng, Miao1,2,3; Zhou, Jianhui2,3; Fang, Feifei2,3; Xu, Zichao2,3; Zheng, Fuqiang2,3; Jiang, Zhidong2,3; Liu, Tao1,2,3; Liu, Hong2,3,4; Zhao, Linxiang1; Zhou, Yu2,3,4
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2022-11-08
页码6
ISSN号2052-4129
DOI10.1039/d2qo01529c
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Zhao, Linxiang(linxiang.zhao@vip.sina.com) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要A substrate-controlled Ru(ii)-catalyzed C-H activation/[5 + 2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds are reported. The most pronounced advantage is that this strategy can offer a highly selective C-H activation of N-benzamidine indoline with two reaction sites prone to C-H activation to selectively prepare a 1,7-fused indoline scaffold and a C7-alkylated/N '-acylated indoline ring by varying its diazo synthons. More importantly, the NH directing group of N-aryl benzamidines is fully utilized and atom-economically integrated into the target products with a good yield and broad substrate scope.
WOS关键词DIAZO-COMPOUNDS ; DIVERGENT COUPLINGS ; BOND ACTIVATION ; IMIDAMIDES ; FUNCTIONALIZATION ; ACCESS ; ISOQUINOLINES ; CYCLIZATION ; ALKALOIDS ; AMIDINES
资助项目National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; [82173656] ; [21977106] ; [82151219] ; [SIMM010109] ; [SIMM010111]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000885330200001
源URL[http://119.78.100.183/handle/2S10ELR8/304686]  
专题中国科学院上海药物研究所
通讯作者Liu, Hong; Zhao, Linxiang; Zhou, Yu
作者单位1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drugs Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Zheng, Miao,Zhou, Jianhui,Fang, Feifei,et al. A substrate-controlled Ru(ii)-catalyzed C-H activation/[5+2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds[J]. ORGANIC CHEMISTRY FRONTIERS,2022:6.
APA Zheng, Miao.,Zhou, Jianhui.,Fang, Feifei.,Xu, Zichao.,Zheng, Fuqiang.,...&Zhou, Yu.(2022).A substrate-controlled Ru(ii)-catalyzed C-H activation/[5+2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds.ORGANIC CHEMISTRY FRONTIERS,6.
MLA Zheng, Miao,et al."A substrate-controlled Ru(ii)-catalyzed C-H activation/[5+2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds".ORGANIC CHEMISTRY FRONTIERS (2022):6.

入库方式： OAI收割

来源：上海药物研究所

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