Pharmaceutical liposomal delivery-specific considerations of innovation and challenges
文献类型：期刊论文
| 作者 | Peng, Taoxing1,2; Xu, Weihua2; Li, Qianqian2; Ding, Yang1; Huang, Yongzhuo2,3,4
|
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2022-11-14 |
| 页码 | 14 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/d2bm01252a |
| 通讯作者 | Ding, Yang(dydszyzf@163.com) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Liposomal technology has been widely used in the pharmaceutical field for the preparation of nano-sized drug delivery systems based on natural or synthetic lipids. Liposomes possess many attractive properties, such as easy processing, high biocompatibility, adaptable drug loading, and improved PK profiles. In recent decades, great efforts have been made in this field, and dozens of liposomal medicines have been marketed worldwide and many more are under preclinical or clinical investigations. Liposomes can enhance the aqueous dissolution and stability of the encapsulated drugs and modulate the in vivo fate of the drugs (e.g., prolonged half-life and increased drug accumulation in the pathological sites). Therefore, liposomal technology can improve the druggability of the candidates, enhance treatment efficacy and reduce side effects. This review discusses the prospects of liposomal delivery, including the specific considerations of innovation and challenges. |
| WOS关键词 | AMPHOTERICIN-B AMBISOME ; ENHANCED PERMEABILITY ; CLINICAL TRANSLATION ; MICROFLUIDIC TECHNOLOGIES ; CONVENTIONAL DOXORUBICIN ; TARGETING CHEMOTHERAPY ; REDUCED CARDIOTOXICITY ; CATIONIC LIPIDS ; DRUG-DELIVERY ; MESSENGER-RNA |
| 资助项目 | National Key Research and Development Program of China, China[2021YFE0103100] ; National Key Research and Development Program of China, China[2021YFC2400600] ; NFSC[81925035] ; Shanghai SciTech Innovation Initiative[19431903100] ; Shanghai SciTech Innovation Initiative[18430740800] ; High-Level Innovative Research Institute[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000885105200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304689]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Yang; Huang, Yongzhuo |
| 作者单位 | 1.China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan 528437, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Taoxing,Xu, Weihua,Li, Qianqian,et al. Pharmaceutical liposomal delivery-specific considerations of innovation and challenges[J]. BIOMATERIALS SCIENCE,2022:14. |
| APA | Peng, Taoxing,Xu, Weihua,Li, Qianqian,Ding, Yang,&Huang, Yongzhuo.(2022).Pharmaceutical liposomal delivery-specific considerations of innovation and challenges.BIOMATERIALS SCIENCE,14. |
| MLA | Peng, Taoxing,et al."Pharmaceutical liposomal delivery-specific considerations of innovation and challenges".BIOMATERIALS SCIENCE (2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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