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Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis

文献类型：期刊论文

作者Zhao, Chuan-Rong1,2,3; Li, Jingyi4; Jiang, Zhi-Tong1,2,3,5; Zhu, Juan-Juan1,2,3; Zhao, Jia-Nan1,2,3; Yang, Qian-Ru1,2,3; Yao, Weijuan1; Pang, Wei1; Li, Ning6,7,8; Yu, Miaorong4,9
刊名SMALL
出版日期2022-11-20
页码15
ISSN号1613-6810
关键词atherosclerosis decitabine endothelial inflammation hemodynamics nanoparticles
DOI10.1002/smll.202204694
通讯作者Yu, Miaorong(mryu@simm.ac.cn) ; Gan, Yong(ygan@simm.ac.cn) ; Zhou, Jing(jzhou@bjmu.edu.cn)
英文摘要Disturbed blood flow induces endothelial pro-inflammatory responses that promote atherogenesis. Nanoparticle-based therapeutics aimed at treating endothelial inflammation in vasculature where disturbed flow occurs may provide a promising avenue to prevent atherosclerosis. By using a vertical-step flow apparatus and a microfluidic chip of vascular stenosis, herein, it is found that the disk-shaped versus the spherical nanoparticles exhibit preferential margination (localization and adhesion) to the regions with the pro-atherogenic disturbed flow. By employing a mouse model of carotid partial ligation, superior targeting and higher accumulation of the disk-shaped particles are also demonstrated within disturbed flow areas than that of the spherical particles. In hyperlipidemia mice, administration of disk-shaped particles loaded with hypomethylating agent decitabine (DAC) displays greater anti-inflammatory and anti-atherosclerotic effects compared with that of the spherical counterparts and exhibits reduced toxicity than "naked" DAC. The findings suggest that shaping nanoparticles to disk is an effective strategy for promoting their delivery to atheroprone endothelia.
WOS关键词IN-VIVO ; SHAPE ; NANOPARTICLES ; ADHESION ; CELLS ; ENDOTHELIUM ; DECITABINE ; PARTICLES ; MECHANISM ; DYNAMICS
资助项目National Natural Science Foundation of China ; Ministry of Science and Technology ; [32201071] ; [81974052] ; [82270419] ; [81921001] ; [82073773] ; [82025032] ; [2022YFC2704300]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000888373300001
源URL[http://119.78.100.183/handle/2S10ELR8/304698]  
专题新药研究国家重点实验室
通讯作者Yu, Miaorong; Gan, Yong; Zhou, Jing
作者单位1.Peking Univ, Hemorheol Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Natl Hlth Commiss Key Lab Cardiovasc Mol Biol & Re, Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Cardiovasc Surg, Shenzhen 518036, Peoples R China
6.Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
8.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Chuan-Rong,Li, Jingyi,Jiang, Zhi-Tong,et al. Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis[J]. SMALL,2022:15.
APA Zhao, Chuan-Rong.,Li, Jingyi.,Jiang, Zhi-Tong.,Zhu, Juan-Juan.,Zhao, Jia-Nan.,...&Zhou, Jing.(2022).Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis.SMALL,15.
MLA Zhao, Chuan-Rong,et al."Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis".SMALL (2022):15.

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来源：上海药物研究所

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