Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson
文献类型：期刊论文
| 作者 | Wang, Ai-Zhu1,2; Han, Hua2,4; Fang, Qiang-Qiang1; Tan, Chang-Heng1,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 205页码:9 |
| 关键词 | Hypericum acmosepalum Hypericaceae PPAPs Anti -hyperglycemia Hyperacmotones a -f |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2022.113482 |
| 通讯作者 | Han, Hua(hanhua@tongji.edu.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn) |
| 英文摘要 | Hyperacmotone A, a polycyclic polyprenylated acylphloroglucinol (PPAP) with an unprecedented skeleton, along with five undescribed congeners and eleven reported ones, was isolated from Hypericum acmosepalum. Hyperacmotone A possesses a unique monocyclic ring skeleton based on a cyclopent-4-ene-1,3-dione acylphloroglucinol core. Their structures were elucidated by extensive analysis of HRESIMS, NMR, biogenetic pathway, and quantum-chemical calculations. In addition, hypercohone G exhibited significant protective effects on high-glucose-injured HUVECs. |
| WOS关键词 | PHLOROGLUCINOL DERIVATIVES ; NATURAL-PRODUCTS ; CLINICAL CONSEQUENCES ; VASCULAR-DISEASE ; MEDICAL THERAPY ; PATHOPHYSIOLOGY ; PERMEABILITY ; GLYCOCALYX ; FLOWERS |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China ; [2019ZX09201001and 2018ZX09735001-002-005] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000880850100005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304704]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Han, Hua; Tan, Chang-Heng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China 2.Tongji Univ, Sch Med, Shanghai 200092, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Tongji Univ, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ai-Zhu,Han, Hua,Fang, Qiang-Qiang,et al. Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson[J]. PHYTOCHEMISTRY,2023,205:9. |
| APA | Wang, Ai-Zhu,Han, Hua,Fang, Qiang-Qiang,&Tan, Chang-Heng.(2023).Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson.PHYTOCHEMISTRY,205,9. |
| MLA | Wang, Ai-Zhu,et al."Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson".PHYTOCHEMISTRY 205(2023):9. |
入库方式： OAI收割
来源：上海药物研究所
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