Danzhi Xiaoyao Powder is a classical prescription for anxiety. This study aims to analyze the effect of this medicine on mitochondrial morphology and function of anxiety rats and explore the mechanism of it against anxiety. Specifically, uncertain empty bottle drinking water stimulation (21 days) was employed to induce anxiety in rats. The elevated plus-maze test and open field test were respectively performed on the 7th, the 14th, and the 21st days of the stimulation, so as to detect the anxiety-related protein index brain-derived neurotrophic factor (BDNF) and evaluate the anxiety level of animals. On this basis, the effect of this prescription on anxiety rats was preliminarily evaluated. After the behavioral test on the 21st day, rats were killed and the brain tissues were separated for the observation of the mitochondrial morphology and the determination of mitochondrial function-related indicators and the adenosine 5′-monophosphate -activated protein kinase (AMPK) level. The results showed that Danzhi Xiaoxiao Powder could alleviate the anxiety-like behavior of rats, significantly increase the percentage of time in open arm in elevated plus-maze test and the ration of activity time in the central area of the field, dose-dependently raise the activity levels of respiratory chain complex I, II, III and IV and the adenosine triphosphate (ATP) content, and elevate the levels of BDNF and phosphorylated AMPK (p-AMPK). Clear structure and intact morphology of mitochondrial cristae in medial prefrontal cortex cells and amygdala were observed in the Danzhi Xiaoyao Powder group. In summary, Danzhi Xiaoyao Powder exerts therapeutic effect on anxiety, and the mechanism is the likelihood that p-AMPK protects the structure and maintains the function of mitochondria.

情绪调节在社会情境中对认知和情感共情的影响尚待厘清,这一问题的阐明将有助于理解社会交互中负性情绪的产生和影响机制,为未来的社会认知干预提供理论基础。本文通过问卷调查验证了共情、情绪调节与负性情绪之间的关系,并采用中文版共情准确性任务探讨认知重评策略使用对共情情绪反应的影响。结果发现:情感共情与日常生活中更多的焦虑和压力有关,而认知共情与更少的抑郁情绪相关,认知重评和表达抑制均在共情与负性情绪之间起保护性调节作用;共情准确性任务中,使用认知重评策略能提高个体对他人消极情绪的共情准确性、降低自身的负性情绪体验;在积极情境下还可以增强个体的积极情绪。结果表明情绪调节,特别是认知重评,在认知和情感共情与负性情绪之间发挥着重要作用。

国家自然科学基金面上项目(31871114)