Two dimensional measurements of receptor ligand interactions
文献类型：期刊论文
| 作者 | Zheng SJ(郑松杰); Zou M(邹敏); Shao YF(邵颖峰) ; Wu, Huaping4; Wu, Helong4; Wang XH(王小环)
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| 刊名 | FRONTIERS IN MOLECULAR BIOSCIENCES
 |
| 出版日期 | 2023-02-17 |
| 卷号 | 10页码:1154074 |
| 关键词 | receptor ligand interaction binding kinetics kinetic on rate kinetic off rate binding affinity two dimensional measuring methods |
| DOI | 10.3389/fmolb.2023.1154074 |
| 英文摘要 | Gaining insight into the two dimensional receptor ligand interactions, which play a significant role in various pivotal biological processes such as immune response and cancer metastasis, will deepen our understanding of numerous physiological and pathological mechanisms and contribute to biomedical applications and drug design. A central issue involved is how to measure the in situ receptor ligand binding kinetics. Here, we review several representative mechanical based and fluorescence based methods, and briefly discuss the strengths and weaknesses for each method. In addition, we emphasize the great importance of the combination of experimental and computational methods in studying the receptor ligand interactions, and further studies should focus on the synergistic development of experimental and computational methods. |
| 分类号 | 二类/Q1 |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000943037100001 |
| 资助机构 | Programs in the National Natural Science Foundation of China [12232019] |
| 其他责任者 | Wu, HP ; Wu, HL (corresponding author), Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China. ; Wang, XH (corresponding author), Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China. |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/91780]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Mech, Beijing, Peoples R China 2.Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China 3.Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng SJ,Zou M,Shao YF,et al. Two dimensional measurements of receptor ligand interactions[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2023,10:1154074. |
| APA | 郑松杰,邹敏,邵颖峰,Wu, Huaping,Wu, Helong,&王小环.(2023).Two dimensional measurements of receptor ligand interactions.FRONTIERS IN MOLECULAR BIOSCIENCES,10,1154074. |
| MLA | 郑松杰,et al."Two dimensional measurements of receptor ligand interactions".FRONTIERS IN MOLECULAR BIOSCIENCES 10(2023):1154074. |
入库方式： OAI收割
来源：力学研究所
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