Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates
文献类型：期刊论文
| 作者 | Wang, Zheng; Yang, Chun; Guan DS(关东石); Li, Jiaqi ; Zhang, Hong
|
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2023-06-05 |
| 卷号 | 58期号:11页码:919 |
| ISSN号 | 1534-5807 |
| DOI | 10.1016/j.devcel.2023.04.004 |
| 英文摘要 | Interfacial tension governs the behaviors and physiological functions of multiple biological condensates dur-ing diverse biological processes. Little is known about whether there are cellular surfactant factors that regu-late the interfacial tension and functions of biological condensates within physiological environments. TFEB, a master transcription factor that controls expression of autophagic-lysosomal genes, assembles into tran-scriptional condensates to control the autophagy-lysosome pathway (ALP). Here, we show that interfacial tension modulates the transcriptional activity of TFEB condensates. MLX, MYC, and IPMK act as synergistic surfactants to decrease the interfacial tension and consequent DNA affinity of TFEB condensates. The inter-facial tension of TFEB condensates is quantitatively correlated to their DNA affinity and subsequent ALP ac-tivity. The interfacial tension and DNA affinity of condensates formed by TAZ-TEAD4 are also regulated by the synergistic surfactant proteins RUNX3 and HOXA4. Our results indicate that the interfacial tension and functions of biological condensates can be controlled by cellular surfactant proteins in human cells. |
| 分类号 | 一类 |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001011548600001 |
| 资助机构 | National Natural Science Foundation of China [82188101, 31871426] |
| 其他责任者 | Wang, Z (corresponding author), Inst Biophys, Chinese Acad Sci, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing 100101, Peoples R China. |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/92431]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.{Yang Chun, Li Jiaqi, Zhang Hong} Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China 2.{Guan Dongshi} Chinese Acad Sci Inst Mech State Key Lab Nonlinear Mech Beijing 100190 Peoples R China 3.{Wang Zheng, Yang Chun, Zhang Hong} Inst Biophys Chinese Acad Sci CAS Ctr Excellence Biomacromolecules Natl Lab Biomacromolecules Beijing 100101 Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zheng,Yang, Chun,Guan DS,et al. Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates[J]. DEVELOPMENTAL CELL,2023,58(11):919. |
| APA | Wang, Zheng,Yang, Chun,关东石,Li, Jiaqi,&Zhang, Hong.(2023).Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates.DEVELOPMENTAL CELL,58(11),919. |
| MLA | Wang, Zheng,et al."Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates".DEVELOPMENTAL CELL 58.11(2023):919. |
入库方式： OAI收割
来源：力学研究所
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