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Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling

文献类型：期刊论文

作者Wang, Xiaochen; Li HY(李航宇); Zheng, Yu; Guan DS(关东石); Wang, Aidan; Fan, Qihui; Jiao, Yang; Ye, Fangfu
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2023-07-07
ISSN号1616-301X
关键词biomaterials cell organization collagen extracellular matrix mechanical coupling
DOI10.1002/adfm.202305414
英文摘要Cells in vivo are surrounded by fibrous extracellular matrix (ECM), which can mediate the propagation of active cellular forces through stressed fiber bundles and regulate various biological processes. However, the mechanisms for multi-cellular organization and collective dynamics induced by cell-ECM mechanical couplings, which are crucial for the development of novel ECM-based biomaterial for cell manipulation and biomechanical applications, remain poorly understood. Herein, the authors design an in vitro quasi-3D experimental system and demonstrate a transition between spreading and aggregating in collective organizational behaviors of discrete multi-cellular systems, induced by engineered ECM-cell mechanical coupling, with the observed phenomena and underlying mechanisms differing fundamentally from those of cell monolayers. During the process of collective cell organization, the collagen substrate undergoes reconstruction into a dense fiber network structure, which is correlated with local cellular density and consistent with observed enhanced cells' motility; and the weakening of fiber bundle formation within the hydrogel reduces cells' movement. Moreover, cells can respond to the curvature and shape of the original cell population and form different aggregation patterns. These results elucidate important physical factors involved in collective cell organization and provide important references for potential applications of biomaterials in new therapies and tissue engineering.
分类号一类
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001023448900001
资助机构National Key Research and Development Program of China [2022YFA1405002, 2020YFA0908200, 2021YFA0719302] ; National Natural Science Foundation of China [T2221001, 12074407, 12090054, 11972351] ; Strategic Priority Research Program of Chinese Academy of Sciences [XDB33030300] ; Youth Innovation Promotion Association of CAS [2021007]
其他责任者Ye, FF (corresponding author), Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Peoples R China. ; Fan, QH ; Ye, FF (corresponding author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. ; Jiao, Y (corresponding author), Arizona State Univ, Mat Sci & Engn, Tempe, AZ 85287 USA. ; Jiao, Y (corresponding author), Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA.
源URL[http://dspace.imech.ac.cn/handle/311007/92601]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.{Zheng, Yu, Jiao, Yang} Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA
2.{Wang, Aidan} Aidi Sch, Beijing 100018, Peoples R China
3.{Wang, Xiaochen, Ye, Fangfu} Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Peoples R China
4.{Wang, Xiaochen, Fan, Qihui, Ye, Fangfu} Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China
5.{Wang, Xiaochen, Ye, Fangfu} Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China
6.{Li, Hangyu, Guan, Dongshi} Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
7.{Li, Hangyu, Guan, Dongshi} Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
8.{Zheng, Yu, Jiao, Yang} Arizona State Univ, Mat Sci & Engn, Tempe, AZ 85287 USA
推荐引用方式
GB/T 7714		 Wang, Xiaochen,Li HY,Zheng, Yu,et al. Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling[J]. ADVANCED FUNCTIONAL MATERIALS,2023.
APA Wang, Xiaochen.,李航宇.,Zheng, Yu.,关东石.,Wang, Aidan.,...&Ye, Fangfu.(2023).Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling.ADVANCED FUNCTIONAL MATERIALS.
MLA Wang, Xiaochen,et al."Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling".ADVANCED FUNCTIONAL MATERIALS (2023).

入库方式： OAI收割

来源：力学研究所

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