As the need for image resolution, transmission rate, and integration rises in space remote sensing applications, the charge accumulation-based TDI- CMOS sensor devices evolve fast. This study proposes a TDI-CMOS imaging system based on FPGA to answer the challenge of high-resolution, wide-format multispectral imaging. First, the device selection and stitching design ideas are clarified based on the index requirements of the imaging system; second, the design techniques of the TDI-CMOS imaging system are emphasized, and the implementation methods of critical technologies such as TDI-CMOS timing drive, register configuration, P-spectrum, and B-spectrum image data training, and high-speed data interface design of the imaging system are illustrated; third, the relevant experimental work is described. In conclusion, the experimental work is described, and the experimental findings are examined and interpreted. The experimental findings demonstrate that the imaging system has a signal-to-noise ratio of 45 dB for P-spectrum and 55 dB for B-spectrum and that the resolution of picture elements is 8288 columns for P-spectrum and 2072 columns for B-spectrum.