We have developed a compact, asymmetric three-channel echelle spectrometer with remarkable high-spectral resolution capabilities. In order to achieve the desired spectral resolution, we initially establish a theoretical spectral model based on the two-dimensional coordinates of spot positions corresponding to each wavelength. Next, we present an innovative and refined method for precisely calibrating echelle spectrometers through parameter inversion. Our analysis delves into the complexities of the nonlinear two-dimensional echelle spectrogram. We employ a variety of optimization techniques, such as grid exploration, simulated annealing, genetic algorithms, and genetic simulated annealing (GSA) algorithms, to accurately invert spectrogram parameters. Our proposed GSA algorithm synergistically integrates the strengths of global and local searches, thereby enhancing calibration accuracy. Compared to the conventional grid exploration method, GSA reduces the error function by 22.8%, convergence time by 2.16 times, and calibration accuracy by 7.05 times. Experimental validation involves calibrating a low-pressure mercury lamp, resulting in an average spectral accuracy error of 0.0257 nm after performing crucial parameter inversion. Furthermore, the echelle spectrometer undergoes a laser-induced breakdown spectroscopy experiment, demonstrating exceptional spectral resolution and sub-10 ns time-resolved capability. Overall, our research offers a comprehensive and efficient solution for constructing, modeling, calibrating, and applying echelle spectrometers, significantly enhancing calibration accuracy and efficiency. This work contributes to the advancement of spectrometry and opens up new possibilities for high-resolution spectral analysis across various research and industry domains.