Recent advances and safety issues of transgenic plant-derived vaccines
文献类型：期刊论文
| 作者 | Guan, Zheng-jun; Guo, Bin; Huo, Yan-lin; Guan, Zheng-ping; Dai, Jia-kun; Wei, Ya-hui |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 97期号:7页码:2817-2840 |
| 关键词 | Transgenic Plant Vaccine Safety |
| ISSN号 | 0175-7598 |
| DOI | 10.1007/s00253-012-4566-2 |
| 文献子类 | Review |
| 英文摘要 | Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines. |
| 学科主题 | Biotechnology & Applied Microbiology |
| 出版地 | NEW YORK |
| 电子版国际标准刊号 | 1432-0614 |
| WOS关键词 | TOXIN-B-SUBUNIT ; HEAT-LABILE ENTEROTOXIN ; MOUTH-DISEASE VIRUS ; EPIDEMIC DIARRHEA VIRUS ; TRANSMISSIBLE GASTROENTERITIS VIRUS ; SYNTHETIC NEUTRALIZING EPITOPE ; PROTECTIVE ANTIBODY-RESPONSE ; STRUCTURAL PROTEIN VP1 ; INSULIN FUSION PROTEIN ; HIGH-LEVEL EXPRESSION |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000316481800005 |
| 出版者 | SPRINGER |
| 资助机构 | National Natural ScienceFoundation of China(National Natural Science Foundation of China (NSFC)) ; Opening Foundation of Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) ; Specialized Foundation of Department of Education of Shaanxi Province, China ; Northwestern university graduate self-innovation project ; Yuncheng University Doctor Scientific research project |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28057]  |
| 专题 | 植被与环境变化国家重点实验室 |
| 作者单位 | 1.[Guan, Zheng-jun 2.Yuncheng Univ, Ctr Biol & Chem Exiperiment, Yuncheng 044000, Shanxi, Peoples R China 3.Chinese Acad Sci, Inst Bot, State Key Lab Vegetat & Environm Change, Beijing 100093, Peoples R China 4.Yuncheng Univ, Dept Life Sci, Yuncheng 044000, Shanxi, Peoples R China 5.NW Univ Xian, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Sch Life Sci, Xian 710069, Peoples R China 6.Guo, Bin 7.Acad Sci, Enzyme Engn Inst Shaanxi, Xian 710600, Shaanxi, Peoples R China 8.Nanjing Agr Univ, Dept Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Zheng-jun,Guo, Bin,Huo, Yan-lin,et al. Recent advances and safety issues of transgenic plant-derived vaccines[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2013,97(7):2817-2840. |
| APA | Guan, Zheng-jun,Guo, Bin,Huo, Yan-lin,Guan, Zheng-ping,Dai, Jia-kun,&Wei, Ya-hui.(2013).Recent advances and safety issues of transgenic plant-derived vaccines.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(7),2817-2840. |
| MLA | Guan, Zheng-jun,et al."Recent advances and safety issues of transgenic plant-derived vaccines".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97.7(2013):2817-2840. |
入库方式： OAI收割
来源：植物研究所
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