Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops
文献类型：期刊论文
| 作者 | Brandt, Ronny; Xie, Yakun; Musielak, Thomas; Graeff, Moritz; Stierhof, York-Dieter; Huang, Hai2; Liu, Chun-Ming ; Wenkel, Stephan
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| 刊名 | MECHANISMS OF DEVELOPMENT
 |
| 出版日期 | 2013 |
| 卷号 | 130期号:1页码:25-33 |
| 关键词 | Shoot apical meristem HD-ZIPIII transcription factors LITTLE ZIPPER AGO10 microRNAs microProteins |
| ISSN号 | 0925-4773 |
| DOI | 10.1016/j.mod.2012.06.007 |
| 文献子类 | Article |
| 英文摘要 | Stem cells in the shoot apex of plants produce cells required for the formation of new leaves. Adult leaves are composed of multiple tissue layers arranged along the dorso-ventral (adaxial/abaxial) axis. Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play an important role in the set-up of leaf polarity in plants. Loss of HD-ZIPIII function results in strongly misshapen leaves and in severe cases fosters the consumption of the apical stem cells, thus causing a growth arrest in mutant plants. HD-ZIPIII mRNA is under tight control by microRNAs 165/166. In addition to the microRNA-action a second layer of regulation is established by LITTLE ZIPPER (ZPR)-type microProteins, which can interact with HD-ZIPIII proteins, forming attenuated protein complexes. Here we show that REVOLUTA (REV, a member of the HD-ZIPIII family) directly regulates the expression of ARGONAUTE10 (AGO10), ZPR1 and ZPR3. Because AGO10 was shown to dampen microRNA165/6 function, REV establishes a positive feedback loop on its own activity. Since ZPR-type microProteins are known to reduce HD-ZIPIII protein activity, REV concomitantly establishes a negative feedback loop. We propose that the interconnection of these microRNA/microProtein feedback loops regulates polarity set-up and stem cell activity in plants. (c) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Developmental Biology |
| 出版地 | AMSTERDAM |
| 电子版国际标准刊号 | 1872-6356 |
| WOS关键词 | LEAF POLARITY ; GENE ; WUSCHEL ; FATE ; ESTABLISHMENT ; ARGONAUTE1 ; PHABULOSA ; TARGET ; ZIPPER ; ACTS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000313699900004 |
| 出版者 | ELSEVIER |
| 资助机构 | Deutsche Forschungsgemeinschaft (DFG)(German Research Foundation (DFG)) ; European Union (FP7)(European Commission) ; Robert Bosch Foundation ; Ministry for Agriculture (Bundesanstalt fur Landwirtschaft und Ernahrung |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28070]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Plant Physiol & Ecol, Natl Lab Plant Mol Genet, Shanghai 200032, Peoples R China 2.Univ Tubingen, Ctr Plant Mol Biol ZMBP, D-72076 Tubingen, Germany 3.Chinese Acad Sci, Inst Bot, Key Lab Mol Physiol, Ctr Signal Transduct & Metabol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Brandt, Ronny,Xie, Yakun,Musielak, Thomas,et al. Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops[J]. MECHANISMS OF DEVELOPMENT,2013,130(1):25-33. |
| APA | Brandt, Ronny.,Xie, Yakun.,Musielak, Thomas.,Graeff, Moritz.,Stierhof, York-Dieter.,...&Wenkel, Stephan.(2013).Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops.MECHANISMS OF DEVELOPMENT,130(1),25-33. |
| MLA | Brandt, Ronny,et al."Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops".MECHANISMS OF DEVELOPMENT 130.1(2013):25-33. |
入库方式： OAI收割
来源：植物研究所
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