The ER luminal binding protein (BiP) alleviates Cd2+-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells
文献类型：期刊论文
| 作者 | Xu, Hua1; Xu, Wenzhong; Xi, Hongmei1; Ma, Wenwen; He, Zhenyan ; Ma, Mi
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| 刊名 | JOURNAL OF PLANT PHYSIOLOGY
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| 出版日期 | 2013 |
| 卷号 | 170期号:16页码:1434-1441 |
| 关键词 | BiP protein Bright yellow-2 cells Cadmium ER stress Programmed cell death |
| ISSN号 | 0176-1617 |
| DOI | 10.1016/j.jplph.2013.05.017 |
| 文献子类 | Article |
| 英文摘要 | Cadmium (Cd) is very toxic to plant cells and Cd2+ stress induces programmed cell death (PCD) in Nicotiana tabacum L cv. bright yellow-2 (BY-2) cells. In plants, PCD can be regulated through the endoplasmic reticulum (ER) stress-cell death signaling pathway. However, the mechanism of Cd2+-induced PCD remains unclear. In this study, we found that Cd2+ treatment induced ER stress in tobacco BY-2 cells. The expression of two ER stress markers NtBLP4 and NtPDI and an unfolded protein response related transcription factor NtbZIP60 were upregulated with Cd2+ stress. Meanwhile, the PCD triggered by prolonged Cd2+ stress could be relieved by two ER chemical chaperones, 4-phenylbutyric acid and tauroursodeoxycholic acid. These results demonstrate that the ER stress-cell death signaling pathway participates in the mediation of Cd2+-induced PCD. Furthermore, the ER chaperone AtBiP2 protein alleviated Cd2+-induced ER stress and PCD in BY-2 cells based on the fact that heterologous expression of AtBiP2 in tobacco BY-2 cells reduced the expression of NtBLP4 and a PCD-related gene NtHsr203J under Cd2+ stress conditions. In summary, these results suggest that the ER stress-cell death signaling pathway regulates Cd2+-induced PCD in tobacco BY-2 cells, and that the AtBiP2 protein act as a negative regulator in this process. (C) 2013 Elsevier GmbH. All rights reserved. |
| 学科主题 | Plant Sciences |
| 出版地 | MUNICH |
| 电子版国际标准刊号 | 1618-1328 |
| WOS关键词 | BZIP TRANSCRIPTION FACTOR ; CADMIUM TOXICITY ; CHAPERONE PROTEIN ; ARABIDOPSIS ; APOPTOSIS ; INDUCTION ; IRE1 ; IDENTIFICATION ; ACCUMULATION ; TRANSLATION |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000325301500006 |
| 出版者 | ELSEVIER GMBH |
| 资助机构 | National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)) |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/28139]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hua,Xu, Wenzhong,Xi, Hongmei,et al. The ER luminal binding protein (BiP) alleviates Cd2+-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells[J]. JOURNAL OF PLANT PHYSIOLOGY,2013,170(16):1434-1441. |
| APA | Xu, Hua,Xu, Wenzhong,Xi, Hongmei,Ma, Wenwen,He, Zhenyan,&Ma, Mi.(2013).The ER luminal binding protein (BiP) alleviates Cd2+-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells.JOURNAL OF PLANT PHYSIOLOGY,170(16),1434-1441. |
| MLA | Xu, Hua,et al."The ER luminal binding protein (BiP) alleviates Cd2+-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells".JOURNAL OF PLANT PHYSIOLOGY 170.16(2013):1434-1441. |
入库方式： OAI收割
来源：植物研究所
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